Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47644
Title: Acute kidney injury in Turkey: epidemiological characteristics, etiology, clinical course, and prognosis
Authors: Gursu M.
Yegenaga I.
Tuglular S.
Dursun B.
Bek S.G.
Bardak S.
Onan E.
Derici, Ulver
Dogukan, Ayhan
Sevinc, Mustafa
Kocyigit, Ismail
Altun, Eda
Haras, Ali Burak
Altiparmak, Mehmet Riza
Tonbul, Halil Zeki
Keywords: Acute kidney injury
Etiology
Kidney replacement therapy
Survival
aminoglycoside derivative
amphotericin
colistin
contrast medium
nonsteroid antiinflammatory agent
acute kidney failure
aged
Article
comorbidity
dehydration
disease classification
disease course
end stage renal disease
epidemiological data
female
heart failure
human
liver cirrhosis
major clinical study
male
mortality rate
observational study
pathogenesis
prognosis
prospective study
renal replacement therapy
sepsis
survival rate
Turkey (republic)
complication
heart failure
intensive care unit
retrospective study
risk factor
sepsis
turkey (bird)
Acute Kidney Injury
Aged
Dehydration
Female
Heart Failure
Humans
Intensive Care Units
Male
Prognosis
Retrospective Studies
Risk Factors
Sepsis
Turkey
Publisher: BioMed Central Ltd
Abstract: Background: This study aimed to evaluate the etiologies, comorbidities, and outcomes of acute kidney injury (AKI) in Turkey and determine any potential differences among different geographical parts of the country. Methods: This prospective observational study was conducted by the Acute Kidney Injury Working Group of the Turkish Society of Nephrology. Demographical and clinical data of patients with AKI at the time of diagnosis and at the 1st week and 1st, 3rd, and 6th months of diagnosis were evaluated to determine patient and renal survival and factors associated with patient prognosis. Results: A total of 776 patients were included (54.7% male, median age: 67 years). Prerenal etiologies, including dehydration, heart failure, and sepsis, were more frequent than other etiologies. 58.9% of the patients had at least one renal etiology, with nephrotoxic agent exposure as the most common etiology. The etiologic factors were mostly similar throughout the country. 33.6% of the patients needed kidney replacement therapy. At the 6th month of diagnosis, 29.5% of the patients had complete recovery; 34.1% had partial recovery; 9.5% developed end-stage kidney disease; and 24.1% died. The mortality rate was higher in the patients from the Eastern Anatolian region; those admitted to the intensive care unit; those with prerenal, renal, and postrenal etiologies together, stage 3 AKI, sepsis, cirrhosis, heart failure, and malignancy; those who need kidney replacement therapy; and those without chronic kidney disease than in the other patients. Conclusion: Physicians managing patients with AKI should be alert against dehydration, heart failure, sepsis, and nephrotoxic agent exposure. Understanding the characteristics and outcomes of patients with AKI in their countries would help prevent AKI and improve treatment strategies. © 2022, The Author(s).
URI: https://doi.org/10.1186/s12882-022-02933-1
https://hdl.handle.net/11499/47644
ISSN: 1471-2369
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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