Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47645
Title: CD97 expression level and its effect on cell adhesion in Preeclampsia
Authors: Atigan A.
Tan S.
Cetin H.
Guler O.T.
Ozdamar S.
Karakaya Y.A.
Keywords: Cadherins
CD97
E-cadherin
Integrin beta-4
N-cadherin
Preeclampsia
cadherin
integrin
case control study
cell adhesion
female
human
metabolism
placenta
preeclampsia
pregnancy
prospective study
Cadherins
Case-Control Studies
Cell Adhesion
Female
Humans
Integrins
Placenta
Pre-Eclampsia
Pregnancy
Prospective Studies
Publisher: NLM (Medline)
Abstract: OBJECTIVES: Cellular interactions and cell adhesion underlie preeclampsia (PE). The aim of the current study is to investigate the role of cell adhesion molecules such as CD97, neural (N)-cadherin, epithelial (E) -cadherin and integrin beta-4 in PE. METHODS: This prospective study included 20 pregnant women with PE and a control group of 16 healthy pregnant women who were matched for age, gestational age, gravida and parity. Standard blood tests and placental cell adhesion molecule immunohistochemical staining were examined. RESULTS: The creatinine, uric acid and lactate dehydrogenase (LDH) levels from standard blood tests were found to be statistically higher in the PE group (p?=?0.002, p?=?0.000, p?=?0.001; respectively). In the PE group, the CD97 maternal serum level was statistically significantly lower, as was its immunohistochemical expression in placental sections (p?=?0.028, p?=?0.000; respectively). The E-cadherin expression score was statistically higher in the PE group compared to the control group (3,65?±?1,84 vs 2,06?±?1,76 respectively; p?=?0.003). The N-cadherin expression score was statistically lower in the PE group compared to the control group (1,50?±?0,82 vs 2,43?±?1,59 respectively; p?=?0.049). Integrin beta-4 was not statistically different between groups. CONCLUSIONS: Cellular interaction may be responsible for PE as in cancer. A balance in intercellular communication, as researched in cancer therapy, may offer the solution in PE. © 2022. The Author(s).
URI: https://doi.org/10.1186/s12884-022-05280-z
https://hdl.handle.net/11499/47645
ISSN: 1471-2393
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File SizeFormat 
CD97 expression level.pdf1.42 MBAdobe PDFView/Open
Show full item record



CORE Recommender

SCOPUSTM   
Citations

4
checked on Jun 14, 2024

WEB OF SCIENCETM
Citations

3
checked on Jun 4, 2024

Page view(s)

30
checked on May 27, 2024

Download(s)

18
checked on May 27, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.