CD97 expression level and its effect on cell adhesion in Preeclampsia

Abstract

OBJECTIVES: Cellular interactions and cell adhesion underlie preeclampsia (PE). The aim of the current study is to investigate the role of cell adhesion molecules such as CD97, neural (N)-cadherin, epithelial (E) -cadherin and integrin beta-4 in PE. METHODS: This prospective study included 20 pregnant women with PE and a control group of 16 healthy pregnant women who were matched for age, gestational age, gravida and parity. Standard blood tests and placental cell adhesion molecule immunohistochemical staining were examined. RESULTS: The creatinine, uric acid and lactate dehydrogenase (LDH) levels from standard blood tests were found to be statistically higher in the PE group (p?=?0.002, p?=?0.000, p?=?0.001; respectively). In the PE group, the CD97 maternal serum level was statistically significantly lower, as was its immunohistochemical expression in placental sections (p?=?0.028, p?=?0.000; respectively). The E-cadherin expression score was statistically higher in the PE group compared to the control group (3,65?±?1,84 vs 2,06?±?1,76 respectively; p?=?0.003). The N-cadherin expression score was statistically lower in the PE group compared to the control group (1,50?±?0,82 vs 2,43?±?1,59 respectively; p?=?0.049). Integrin beta-4 was not statistically different between groups. CONCLUSIONS: Cellular interaction may be responsible for PE as in cancer. A balance in intercellular communication, as researched in cancer therapy, may offer the solution in PE. © 2022. The Author(s).