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https://hdl.handle.net/11499/47666
Title: | Serum microRNA signature is capable of predictive and prognostic factor for SARS-COV-2 virulence | Other Titles: | Serum miRNA, SARS-COV-2 virülansı için prediktif ve prognostik faktör yeteneğine sahiptir | Authors: | Demiray, Aydın Sarı, Tuğba Çalışkan, Ahmet Nar, Rukiye Aksoy, Levent Akbubak, İsmail Hakkı |
Keywords: | COVID-19 Hsa-miR-190a MiRNA SARS-CoV-2 Serum |
Publisher: | De Gruyter Open Ltd | Abstract: | Objectives: Coronavirus disease 2019 (COVID-19) is a kind of viral pneumonia which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MicroRNAs (miRNA) are small non-coding RNAs consisting of 19-25 nucleotides and play a role in post-transcriptional gene regulation. We have focused on serum expression levels of microRNA (miRNA) a novel concept of in host-virus interactions. MicroRNA expression profiles were investigated in serum samples of COVID-19 patients. Materials and methods: The samples were collected from 40 patients diagnosed with COVID-19 patients and from 10 healthy controls. Expression profile of 20 miRNAs were examined using a quantitative real-time polymerase chain reaction (qPCR). Results: Statistically significant expression level differences (p < 0.05) were detected in nine miRNAs in COVID-19 patients and healthy controls. 7 miRNAs (hsa-let-7d, hsa-miR-17, hsa-miR-34b, hsa-miR-93, hsa-miR-200b, hsa-miR-200c, hsa-miR-223) expression levels were found to be significantly decreased and the expression levels of 2 miRNAs (hsa-miR-190a and hsa-miR-203) significantly increased respect to healthy controls. Conclusions: We expect that a miRNA profile can be beneficial for the diagnosis of the COVID-19. Our result revealed that the increase in hsa-miR-190a level may be a prognostic factor related to the COVID-19 disease. © 2021 Aydın Demiray et al., published by De Gruyter. International License. | URI: | https://doi.org/10.1515/tjb-2020-0520 https://search.trdizin.gov.tr/yayin/detay/492527 https://hdl.handle.net/11499/47666 |
ISSN: | 0250-4685 |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection |
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Serum-microRNA-signature-is-capable-of-predictive-and-prognostic-factor-for-SARSCOV2-virulenceTurkish-Journal-of-Biochemistry.pdf | 1.24 MB | Adobe PDF | View/Open |
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