Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47666
Title: Serum Microrna Signature Is Capable of Predictive and Prognostic Factor for Sars-Cov Virulence
Other Titles: Serum miRNA, SARS-COV-2 Virülansı için Prediktif ve Prognostik Faktör Yeteneğine Sahiptir
Authors: Demiray, Aydin
Sari, Tugba
Caliskan, Ahmet
Nar, Rukiye
Aksoy, Levent
Akbubak, Ismail Hakki
Keywords: Covid-19
Hsa-Mir-190A
Mirna
Sars-Cov-2
Serum
Publisher: Walter de Gruyter Gmbh
Abstract: Objectives: Coronavirus disease 2019 (COVID-19) is a kind of viral pneumonia which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MicroRNAs (miRNA) are small non-coding RNAs consisting of 19-25 nucleotides and play a role in post-transcriptional gene regulation. We have focused on serum expression levels of microRNA (miRNA) a novel concept of in host-virus interactions. MicroRNA expression profiles were investigated in serum samples of COVID-19 patients. Materials and methods: The samples were collected from 40 patients diagnosed with COVID-19 patients and from 10 healthy controls. Expression profile of 20 miRNAs were examined using a quantitative real-time polymerase chain reaction (qPCR). Results: Statistically significant expression level differences (p < 0.05) were detected in nine miRNAs in COVID-19 patients and healthy controls. 7 miRNAs (hsa-let-7d, hsa-miR-17, hsa-miR-34b, hsa-miR-93, hsa-miR-200b, hsa-miR-200c, hsa-miR-223) expression levels were found to be significantly decreased and the expression levels of 2 miRNAs (hsa-miR-190a and hsa-miR-203) significantly increased respect to healthy controls. Conclusions: We expect that a miRNA profile can be beneficial for the diagnosis of the COVID-19. Our result revealed that the increase in hsa-miR-190a level may be a prognostic factor related to the COVID-19 disease.
Description: Sari, Tugba/0000-0003-3204-2371; Demiray, Aydin/0000-0002-3343-0184
URI: https://doi.org/10.1515/tjb-2020-0520
ISSN: 0250-4685
1303-829X
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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