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https://hdl.handle.net/11499/47690
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DC Field | Value | Language |
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dc.contributor.author | Kurt Kızıldoğan, Aslıhan | - |
dc.contributor.author | Otur, Çiğdem | - |
dc.contributor.author | Yılmaz, Can | - |
dc.contributor.author | Arslan, Şevki | - |
dc.contributor.author | Mutlu, Doğukan | - |
dc.contributor.author | Kıvrak, Arif | - |
dc.contributor.author | Algso, Muheb | - |
dc.contributor.author | Kayhan, Abdussamet | - |
dc.contributor.author | Kayhan, Abdussamet | - |
dc.contributor.author | Çetin, Doğan | - |
dc.contributor.author | Konuş, Metin | - |
dc.date.accessioned | 2023-01-09T21:29:38Z | - |
dc.date.available | 2023-01-09T21:29:38Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1570-1808 | - |
dc.identifier.uri | https://doi.org/10.2174/1570180817999201109203226 | - |
dc.identifier.uri | https://hdl.handle.net/11499/47690 | - |
dc.description.abstract | Aims: In this study experiments were carried out to explore antioxidant, antimicrobial, cytotoxic properties of novel indole derivative 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2-yl-1H-indole (EPI) together with its effect on glutathione S-transferases (GST) activities in human liver carcinoma (HepG2) cells. Background: Indoles probably represent one of the most important heterocyclic structures that have been attracting the interest of many scientists in drug discovery. Objective: The present study was carried out to explore antioxidant, antimicrobial, cytotoxic properties of novel indole derivative 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2-yl-1H-indole (EPI) and its effect on glutathione S-transferases (GST) activities in human liver carcinoma (HepG2) cells. Materials and Methods: Pd-catalyst Sonogashira coupling reactions, MTT Assay, Antioxidant capacity test, Antimicrobial test, GST enzyme activity test Results: 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant and antimicrobial properties. It displayed significant induction in glutathione S-transferases (GST) enzyme activity in human liver cancer cell lines (HepG2), but cytotoxic effect on all tested cancer cell lines could not be observed. Conclusion: All of these results showed that 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant and antimicrobial properties without cytotoxic effect, which could make it a promising active component with further studies.. © 2021 Bentham Science Publishers. | en_US |
dc.description.sponsorship | PAU-BAP-2018-KRM-011; Ondokuz Mayis Üniversitesi: PYO.ZRT.1904.17.053; Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAK: 115Z020, FBA-2018-6901, FYL-2019-8301 | en_US |
dc.description.sponsorship | The authors thank The Scientific and Technological Research Council of Turkey (Project No: 115Z020), Van Yüzüncü Yıl University (FBA-2018-6901 and FYL-2019-8301) and Pamukkale University (PAU-BAP-2018-KRM-011) and Ondokuz Mayıs University (PYO.ZRT.1904.17.053) for financial supporting of reactant and reagents. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Bentham Science Publishers | en_US |
dc.relation.ispartof | Letters in Drug Design and Discovery | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Antimicrobial | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Cytotoxicity | en_US |
dc.subject | Heteroaromatic compounds | en_US |
dc.subject | Indole | en_US |
dc.subject | Small molecules | en_US |
dc.subject | 1 ethyl 2 phenyl 3 phenylethyl 3 thiophen 2 yl 1h indole derivative | en_US |
dc.subject | antiinfective agent | en_US |
dc.subject | antioxidant | en_US |
dc.subject | cytotoxic agent | en_US |
dc.subject | glutathione transferase | en_US |
dc.subject | indole derivative | en_US |
dc.subject | unclassified drug | en_US |
dc.subject | antimicrobial activity | en_US |
dc.subject | antioxidant activity | en_US |
dc.subject | Article | en_US |
dc.subject | cancer cell line | en_US |
dc.subject | controlled study | en_US |
dc.subject | cytotoxicity | en_US |
dc.subject | drug structure | en_US |
dc.subject | drug synthesis | en_US |
dc.subject | enzyme activity | en_US |
dc.subject | Hep-G2 cell line | en_US |
dc.subject | human | en_US |
dc.subject | human cell | en_US |
dc.subject | MTT assay | en_US |
dc.subject | Sonogashira reaction | en_US |
dc.title | Synthesis, cytotoxicity, antioxidant and antimicrobial activity of indole based novel small molecules | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 18 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 461 | en_US |
dc.identifier.endpage | 470 | en_US |
dc.identifier.doi | 10.2174/1570180817999201109203226 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57192710504 | - |
dc.authorscopusid | 57212383363 | - |
dc.authorscopusid | 57221517895 | - |
dc.authorscopusid | 8684142100 | - |
dc.authorscopusid | 57212511655 | - |
dc.authorscopusid | 8694518300 | - |
dc.authorscopusid | 57203329350 | - |
dc.identifier.scopus | 2-s2.0-85116036916 | en_US |
dc.identifier.scopusquality | Q3 | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
crisitem.author.dept | 17.02. Biology | - |
Appears in Collections: | Fen-Edebiyat Fakültesi Koleksiyonu Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection |
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