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https://hdl.handle.net/11499/47690
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DC Field | Value | Language |
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dc.contributor.author | Kurt-Kizildogan, Aslihan | - |
dc.contributor.author | Otur, Cigdem | - |
dc.contributor.author | Yilmaz, Can | - |
dc.contributor.author | Arslan, Sevki | - |
dc.contributor.author | Mutlu, Dogukan | - |
dc.contributor.author | Kivrak, Arif | - |
dc.contributor.author | Konus, Metin | - |
dc.date.accessioned | 2023-01-09T21:29:38Z | - |
dc.date.available | 2023-01-09T21:29:38Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1570-1808 | - |
dc.identifier.issn | 1875-628X | - |
dc.identifier.uri | https://doi.org/10.2174/1570180817999201109203226 | - |
dc.description | Konus, Metin/0000-0002-9953-1375; Cetin, Dogan/0000-0002-5733-4007; Mutlu, Dogukan/0000-0003-3259-5822; Kurt Kizildogan, Aslihan/0000-0002-9323-0993; Kivrak, Arif/0000-0003-4770-2686 | en_US |
dc.description.abstract | Aims: In this study experiments were carried out to explore antioxidant, antimicrobial, cytotoxic properties of novel indole derivative 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2-yl-1Hindole (EPI) together with its effect on glutathione S-transferases (GST) activities in human liver carcinoma (HepG2) cells. Background: Indoles probably represent one of the most important heterocyclic structures that have been attracting the interest of many scientists in drug discovery. Objective: The present study was carried out to explore antioxidant, antimicrobial, cytotoxic properties of novel indole derivative 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2-yl-1H-indole (EPI) and its effect on glutathione S-transferases (GST) activities in human liver carcinoma (HepG2) cells. Materials and Methods: Pd-catalyst Sonogashira coupling reactions, MTT Assay, Antioxidant capacity test, Antimicrobial test, GST enzyme activity test Results: 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant and antimicrobial properties. It displayed significant induction in glutathione S-transferases (GST) enzyme activity in human liver cancer cell lines (HepG2), but cytotoxic effect on all tested cancer cell lines could not be observed. Conclusion: All of these results showed that 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant and antimicrobial properties without cytotoxic effect, which could make it a promising active component with further studies.. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey [115Z020]; Van Yuzuncu Yl University [FBA-2018-6901, FYL-2019-8301]; Pamukkale University [PAU-BAP-2018-KRM-011]; Ondokuz Mays University [PYO.ZRT.1904.17.053] | en_US |
dc.description.sponsorship | The authors thank The Scientific and Technological Re-search Council of Turkey (Project No: 115Z020) , Van Yuzuncu Yl University (FBA-2018-6901 and FYL-2019-8301) and Pamukkale University (PAU-BAP-2018-KRM-011) and Ondokuz Mays University (PYO.ZRT.1904.17.053) for financial supporting of reactant and reagents. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Bentham Science Publ Ltd | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Indole | en_US |
dc.subject | Heteroaromatic Compounds | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Cytotoxicity | en_US |
dc.subject | Antimicrobial | en_US |
dc.subject | Small Molecules | en_US |
dc.title | Synthesis, Cytotoxicity, Antioxidant and Antimicrobial Activity of Indole Based Novel Small Molecules | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 18 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 461 | en_US |
dc.identifier.endpage | 470 | en_US |
dc.department | Pamukkale University | en_US |
dc.authorid | Konus, Metin/0000-0002-9953-1375 | - |
dc.authorid | Cetin, Dogan/0000-0002-5733-4007 | - |
dc.authorid | Mutlu, Dogukan/0000-0003-3259-5822 | - |
dc.authorid | Kurt Kizildogan, Aslihan/0000-0002-9323-0993 | - |
dc.authorid | Kivrak, Arif/0000-0003-4770-2686 | - |
dc.identifier.doi | 10.2174/1570180817999201109203226 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorwosid | Kurt-Kizildogan, Aslihan/Jce-2182-2023 | - |
dc.authorwosid | Mutlu, Dogukan/Aal-4976-2021 | - |
dc.authorwosid | Yilmaz, Can/Grs-2754-2022 | - |
dc.authorwosid | Çetin, Doğan/Abq-1207-2022 | - |
dc.authorwosid | Kurt Kizildogan, Aslihan/A-1199-2019 | - |
dc.authorwosid | Kivrak, Arif/W-2196-2017 | - |
dc.identifier.scopus | 2-s2.0-85116036916 | en_US |
dc.identifier.scopus | 2-s2.0-85116036916 | - |
dc.identifier.wos | WOS:000677488500007 | - |
dc.identifier.scopusquality | Q4 | - |
dc.description.woscitationindex | Science Citation Index Expanded | - |
dc.identifier.wosquality | Q4 | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Article | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | 17.02. Biology | - |
Appears in Collections: | Fen-Edebiyat Fakültesi Koleksiyonu Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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