Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47690
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dc.contributor.authorKurt-Kizildogan, Aslihan-
dc.contributor.authorOtur, Cigdem-
dc.contributor.authorYilmaz, Can-
dc.contributor.authorArslan, Sevki-
dc.contributor.authorMutlu, Dogukan-
dc.contributor.authorKivrak, Arif-
dc.contributor.authorKonus, Metin-
dc.date.accessioned2023-01-09T21:29:38Z-
dc.date.available2023-01-09T21:29:38Z-
dc.date.issued2021-
dc.identifier.issn1570-1808-
dc.identifier.issn1875-628X-
dc.identifier.urihttps://doi.org/10.2174/1570180817999201109203226-
dc.descriptionKonus, Metin/0000-0002-9953-1375; Cetin, Dogan/0000-0002-5733-4007; Mutlu, Dogukan/0000-0003-3259-5822; Kurt Kizildogan, Aslihan/0000-0002-9323-0993; Kivrak, Arif/0000-0003-4770-2686en_US
dc.description.abstractAims: In this study experiments were carried out to explore antioxidant, antimicrobial, cytotoxic properties of novel indole derivative 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2-yl-1Hindole (EPI) together with its effect on glutathione S-transferases (GST) activities in human liver carcinoma (HepG2) cells. Background: Indoles probably represent one of the most important heterocyclic structures that have been attracting the interest of many scientists in drug discovery. Objective: The present study was carried out to explore antioxidant, antimicrobial, cytotoxic properties of novel indole derivative 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2-yl-1H-indole (EPI) and its effect on glutathione S-transferases (GST) activities in human liver carcinoma (HepG2) cells. Materials and Methods: Pd-catalyst Sonogashira coupling reactions, MTT Assay, Antioxidant capacity test, Antimicrobial test, GST enzyme activity test Results: 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant and antimicrobial properties. It displayed significant induction in glutathione S-transferases (GST) enzyme activity in human liver cancer cell lines (HepG2), but cytotoxic effect on all tested cancer cell lines could not be observed. Conclusion: All of these results showed that 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant and antimicrobial properties without cytotoxic effect, which could make it a promising active component with further studies..en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [115Z020]; Van Yuzuncu Yl University [FBA-2018-6901, FYL-2019-8301]; Pamukkale University [PAU-BAP-2018-KRM-011]; Ondokuz Mays University [PYO.ZRT.1904.17.053]en_US
dc.description.sponsorshipThe authors thank The Scientific and Technological Re-search Council of Turkey (Project No: 115Z020) , Van Yuzuncu Yl University (FBA-2018-6901 and FYL-2019-8301) and Pamukkale University (PAU-BAP-2018-KRM-011) and Ondokuz Mays University (PYO.ZRT.1904.17.053) for financial supporting of reactant and reagents.en_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIndoleen_US
dc.subjectHeteroaromatic Compoundsen_US
dc.subjectAntioxidanten_US
dc.subjectCytotoxicityen_US
dc.subjectAntimicrobialen_US
dc.subjectSmall Moleculesen_US
dc.titleSynthesis, Cytotoxicity, Antioxidant and Antimicrobial Activity of Indole Based Novel Small Moleculesen_US
dc.typeArticleen_US
dc.identifier.volume18en_US
dc.identifier.issue5en_US
dc.identifier.startpage461en_US
dc.identifier.endpage470en_US
dc.departmentPamukkale Universityen_US
dc.authoridKonus, Metin/0000-0002-9953-1375-
dc.authoridCetin, Dogan/0000-0002-5733-4007-
dc.authoridMutlu, Dogukan/0000-0003-3259-5822-
dc.authoridKurt Kizildogan, Aslihan/0000-0002-9323-0993-
dc.authoridKivrak, Arif/0000-0003-4770-2686-
dc.identifier.doi10.2174/1570180817999201109203226-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorwosidKurt-Kizildogan, Aslihan/Jce-2182-2023-
dc.authorwosidMutlu, Dogukan/Aal-4976-2021-
dc.authorwosidYilmaz, Can/Grs-2754-2022-
dc.authorwosidÇetin, Doğan/Abq-1207-2022-
dc.authorwosidKurt Kizildogan, Aslihan/A-1199-2019-
dc.authorwosidKivrak, Arif/W-2196-2017-
dc.identifier.scopus2-s2.0-85116036916en_US
dc.identifier.scopus2-s2.0-85116036916-
dc.identifier.wosWOS:000677488500007-
dc.identifier.scopusqualityQ4-
dc.description.woscitationindexScience Citation Index Expanded-
dc.identifier.wosqualityQ4-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.grantfulltextnone-
item.fulltextNo Fulltext-
crisitem.author.dept17.02. Biology-
Appears in Collections:Fen-Edebiyat Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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