Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47778
Title: Does Fludrocortisone Treatment Cause Hypomagnesemia in Children With Primary
Authors: Erbas, Ibrahim Mert
Altincik, Selda Ayca
Catli, Gonul
Unuvar, Tolga
Ozhan, Bayram
Abaci, Ayhan
Anik, Ahmet
Keywords: Mineralocorticoids
Magnesium
Magnesuria
Pediatrics
Primary Adrenal Insufficiency
Publisher: Tubitak Scientific & Technological Research Council Turkey
Abstract: Background/aim: Aldosterone is a mineralocorticoid that secreted from adrenal glands and a known factor to increase magnesium excretion by direct and indirect effects on renal tubular cells. Although the frequency of hypomagnesemia was found to be approximately 5% in adult studies, there is no study in the literature investigating the frequency of hypomagnesemia in children by using fludrocortisone, which has a mineralocorticoid activity. Materials and methods: A multi-center retrospective study was conducted, including children who were under fludrocortisone treatment for primary adrenal insufficiency and applied to participant pediatric endocrinology outpatient clinics. Results: Forty-three patients (58.1% male, 41.9% prepubertal) included in the study, whose median age was 9.18 (0.61-19) years, and the most common diagnosis among the patients was a salt-wasting form of congenital adrenal hyperplasia (67.4%). Mean serum magnesium level was 2.05 (+/- 0.13) mg/dL, and hypomagnesemia was not observed in any of the patients treated with fludrocortisone. None of the patients had increased urinary excretion of magnesium. Conclusion: Unlike the studies performed in adults, we could not find any evidence of magnesium wasting effect of fludrocortisone treatment with normal or even high doses in children and adolescents.
Description: Abaci, Ayhan/0000-0002-1812-0321; Catli, Gonul/0000-0002-0488-6377; Erbas, Ibrahim Mert/0000-0001-9368-8868; Altincik, Selda Ayca/0000-0002-4101-9299
URI: https://doi.org/10.3906/sag-2008-167
ISSN: 1300-0144
1303-6165
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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