Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47813
Title: Cord Blood Levels of Spexin, Leptin, and Visfatin in Term Infants Born Small, Appropriate, and Large for Gestational Age and Their Association with Newborn Anthropometric Measurements
Authors: Pekal, Yücel
Özhan, Bayram
Enli, Yaşar
Özdemir, Özmert M.A.
Ergin, Hacer
Keywords: Adipokine
antropometry
newborn
speksin
umblical cord
adipocytokine
leptin
nicotinamide phosphoribosyltransferase
tumor necrosis factor
anthropometry
Article
birth length
birth weight
body mass
body weight
breast feeding
cesarean section
depression
enzyme linked immunosorbent assay
gene expression
head circumference
homeostasis model assessment
human
insulin resistance
large for gestational age
maternal serum
menstrual cycle
oral glucose tolerance test
preeclampsia
protein blood level
small for date infant
umbilical cord blood
vitamin D deficiency
body weight gain
child
female
fetus blood
gestational age
infant
intrauterine growth retardation
male
newborn
obesity
Birth Weight
Child
Female
Fetal Blood
Fetal Growth Retardation
Gestational Age
Humans
Infant
Infant, Newborn
Infant, Small for Gestational Age
Leptin
Male
Nicotinamide Phosphoribosyltransferase
Obesity
Weight Gain
Publisher: Galenos Publishing House
Abstract: Objective: Children born small for gestational age (SGA) are at risk of future obesity and associated comorbidities. Therefore the identification of risk factors and novel biomarkers which are associated with this risk are needed for early detection and to improve preventive strategies. Spexin (SPX), a novel neuropeptide that is involved in the regulation of obesity and fat metabolism, is a candidate biomarker for predicting obesity and related comorbidities at an early age. The aim of this study was to investigate serum levels of SPX in term infants born small, appropriate, and large for gestational age (LGA) and its association with newborn anthropometric measurements. Methods: One hundred and twenty term newborn babies classified as SGA, appropriate for gestational age (AGA), or LGA and their mothers were included. SPX, leptin and visfatin were measured in cord blood and maternal serum by enzyme-linked immunosorbent assay. Results: Fifty-six (46.7%) neonates were girls and 64 (53.3%) were boys. The mean birth weight was 3170.70±663 g, birth length was 48.9±2.79 cm, and head circumference was 34.5±1.67 cm. Birth weights, lengths, and head circumferences of the neonates in the SGA, AGA, and LGA groups were significantly different. Cord blood SPX and leptin levels in the SGA groups were significantly lower than those of both the LGA and AGA groups. Cord blood visfatin levels were significantly lower in the AGA group than the LGA and SGA groups. Maternal SPX levels of SGA babies were significantly lower than those of the mothers in both the LGA and AGA groups, but no significant difference was observed between the SGA and LGA groups. Maternal visfatin levels of the AGA babies were significantly higher than the maternal levels of SGA and LGA groups. There was no difference in terms of maternal leptin levels. Cord blood SPX and leptin levels were positively correlated with birth weight, length and head circumference. Birth weight increased significantly in line with maternal pregestational body mass index. Conclusion: The lowest SPX levels were found in the SGA babies and cord SPX level was significantly correlated with newborn length, weight, and head circumference. © 2022 by Turkish Society for Pediatric Endocrinology and Diabetes The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House.
URI: https://doi.org/10.4274/jcrpe.galenos.2022.2022-4-24
https://hdl.handle.net/11499/47813
ISSN: 1308-5727
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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