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https://hdl.handle.net/11499/47813
Title: | Cord Blood Levels of Spexin, Leptin, and Visfatin in Term Infants Born Small, Appropriate, and Large for Gestational Age and Their Association with Newborn Anthropometric Measurements | Authors: | Pekal, Yücel Özhan, Bayram Enli, Yaşar Özdemir, Özmert M.A. Ergin, Hacer |
Keywords: | Adipokine antropometry newborn speksin umblical cord adipocytokine leptin nicotinamide phosphoribosyltransferase tumor necrosis factor anthropometry Article birth length birth weight body mass body weight breast feeding cesarean section depression enzyme linked immunosorbent assay gene expression head circumference homeostasis model assessment human insulin resistance large for gestational age maternal serum menstrual cycle oral glucose tolerance test preeclampsia protein blood level small for date infant umbilical cord blood vitamin D deficiency body weight gain child female fetus blood gestational age infant intrauterine growth retardation male newborn obesity Birth Weight Child Female Fetal Blood Fetal Growth Retardation Gestational Age Humans Infant Infant, Newborn Infant, Small for Gestational Age Leptin Male Nicotinamide Phosphoribosyltransferase Obesity Weight Gain |
Publisher: | Galenos Publishing House | Abstract: | Objective: Children born small for gestational age (SGA) are at risk of future obesity and associated comorbidities. Therefore the identification of risk factors and novel biomarkers which are associated with this risk are needed for early detection and to improve preventive strategies. Spexin (SPX), a novel neuropeptide that is involved in the regulation of obesity and fat metabolism, is a candidate biomarker for predicting obesity and related comorbidities at an early age. The aim of this study was to investigate serum levels of SPX in term infants born small, appropriate, and large for gestational age (LGA) and its association with newborn anthropometric measurements. Methods: One hundred and twenty term newborn babies classified as SGA, appropriate for gestational age (AGA), or LGA and their mothers were included. SPX, leptin and visfatin were measured in cord blood and maternal serum by enzyme-linked immunosorbent assay. Results: Fifty-six (46.7%) neonates were girls and 64 (53.3%) were boys. The mean birth weight was 3170.70±663 g, birth length was 48.9±2.79 cm, and head circumference was 34.5±1.67 cm. Birth weights, lengths, and head circumferences of the neonates in the SGA, AGA, and LGA groups were significantly different. Cord blood SPX and leptin levels in the SGA groups were significantly lower than those of both the LGA and AGA groups. Cord blood visfatin levels were significantly lower in the AGA group than the LGA and SGA groups. Maternal SPX levels of SGA babies were significantly lower than those of the mothers in both the LGA and AGA groups, but no significant difference was observed between the SGA and LGA groups. Maternal visfatin levels of the AGA babies were significantly higher than the maternal levels of SGA and LGA groups. There was no difference in terms of maternal leptin levels. Cord blood SPX and leptin levels were positively correlated with birth weight, length and head circumference. Birth weight increased significantly in line with maternal pregestational body mass index. Conclusion: The lowest SPX levels were found in the SGA babies and cord SPX level was significantly correlated with newborn length, weight, and head circumference. © 2022 by Turkish Society for Pediatric Endocrinology and Diabetes The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House. | URI: | https://doi.org/10.4274/jcrpe.galenos.2022.2022-4-24 https://hdl.handle.net/11499/47813 |
ISSN: | 1308-5727 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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