Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47830
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dc.contributor.authorAkgün, Alperen Emre-
dc.contributor.authorYaylalı, Yalın Tolga-
dc.contributor.authorSeçme, Mücahit-
dc.contributor.authorDodurga, Yavuz-
dc.contributor.authorŞenol, Hande-
dc.date.accessioned2023-01-09T21:30:16Z-
dc.date.available2023-01-09T21:30:16Z-
dc.date.issued2022-
dc.identifier.issn2149-2263-
dc.identifier.urihttps://doi.org/10.5152/AnatolJCardiol.2021.861-
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/521492-
dc.identifier.urihttps://hdl.handle.net/11499/47830-
dc.description.abstractBackground: Dysregulation of microRNAs is associated with pulmonary hypertension. The present study aimed to determine the alterations in microRNA and microRNA expressions and their role in signaling pathways and investigate the relationship with serum levels of apelin, kynurenine, and endocan in pulmonary hypertension. Methods: The study design was prospective and single-centered. The study included 32 consecutive treatment-naive patients with precapillary pulmonary hypertension and 55 age and sex-matched healthy controls. All subjects underwent right heart catheterization. mRNA expressions of hypoxia-inducible factor-1 alpha, hypoxia-inducible factor-2 alpha, signal transducer and activator of transcription-3, fibroblast growth factor-2, fibroblast growth factor receptor-1, and poly-ADP-ribose polymerase-1 and microRNA expressions of miRNA-210, miRNA-130a, miRNA-424, miRNA-204, and miRNA-223 were determined by RT-PCR. Concentrations of kynurenine, apelin, and endocan were analyzed by ELISA. Results: mRNA expressions of hypoxia-inducible factor-2 alpha, signal transducer and activator of transcription-33, and FGF-2 were increased; miRNA-210 and miRNA-130a were increased; miRNA-223 and miRNA-204 were decreased in pulmonary hypertension. Apelin and kynurenine concentrations were decreased in pulmonary hypertension. There were positive correlations: hypoxia-inducible factor-2 alpha-miRNA-424, ApelinmiRNA-424, kynurenine-miRNA-210, signal transducer and activator of transcription-3-PVR, miRNA-210-right atrial pressure, and kynurenine-right atrial pressure. There were negative correlations: poly-ADP-ribose polymerase-1-miRNA-210 and poly-ADP-ribose polymerase-1-right atrial pressure. On multiple logistic regression analyses, miRNA-130a and Apelin were independent risk factors for PH. Conclusions: We report a novel relationship between the kynurenine and poly-ADPribose polymerase-1 signaling pathways that could be mediated by miRNA-210. We also report a connection between the Apelin and hypoxia-inducible factor-2 alpha signaling pathways that could be mediated by miRNA-424. Reduced levels of Apelin and elevated levels of miRNA-130a are associated with pulmonary hypertension. We also find that elevated levels of signal transducer and activator of transcription-3, miRNA-210, and kynurenine and reduced levels of poly-ADP-ribose polymerase-1 correlate with more severe hemodynamics. © 2022 Turkish Society of Cardiology. All rights reserved.en_US
dc.description.sponsorship2018TIPF023en_US
dc.description.sponsorshipFunding: The authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation. A. Akgün and Y.T. Yaylalı contributed equally to this work. This study was supported by Pamukkale University Scientific Research Projects Coordination Unit through project number 2018TIPF023.en_US
dc.language.isoenen_US
dc.publisherTurkish Society of Cardiologyen_US
dc.relation.ispartofAnatolian Journal of Cardiologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectkynurenineen_US
dc.subjectMicroRNAen_US
dc.subjectpoly-ADP-ribose polymerase-1en_US
dc.subjectpulmonary hypertensionen_US
dc.subjectapelinen_US
dc.subjectendocanen_US
dc.subjectfibroblast growth factor 2en_US
dc.subjectfibroblast growth factor receptor 1en_US
dc.subjecthypoxia inducible factor 1alphaen_US
dc.subjecthypoxia inducible factor 2alphaen_US
dc.subjectkynurenineen_US
dc.subjectmembrane proteinen_US
dc.subjectmicroRNA 130aen_US
dc.subjectmicroRNA 204en_US
dc.subjectmicroRNA 210en_US
dc.subjectmicroRNA 223en_US
dc.subjectmicroRNA 424en_US
dc.subjectnicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1en_US
dc.subjectSTAT3 proteinen_US
dc.subjectunclassified drugen_US
dc.subjectadenosine diphosphate riboseen_US
dc.subjectapelinen_US
dc.subjectkynurenineen_US
dc.subjectmessenger RNAen_US
dc.subjectmicroRNAen_US
dc.subjectMIRN204 microRNA, humanen_US
dc.subjectMIRN210 microRNA, humanen_US
dc.subjectnicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferaseen_US
dc.subjectnicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitoren_US
dc.subjectadulten_US
dc.subjectArticleen_US
dc.subjectassessment of humansen_US
dc.subjectcardiac indexen_US
dc.subjectchronic thromboembolic pulmonary hypertensionen_US
dc.subjectclinical articleen_US
dc.subjectclinical assessmenten_US
dc.subjectclinical featureen_US
dc.subjectcontrolled studyen_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjectfemaleen_US
dc.subjectheart catheterizationen_US
dc.subjectheart hemodynamicsen_US
dc.subjectheart right atrium pressureen_US
dc.subjecthumanen_US
dc.subjectlung vascular resistanceen_US
dc.subjectmaleen_US
dc.subjectmRNA expression levelen_US
dc.subjectoutcome assessmenten_US
dc.subjectprospective studyen_US
dc.subjectprotein expressionen_US
dc.subjectpulmonary hypertensionen_US
dc.subjectreverse transcription polymerase chain reactionen_US
dc.subjectRNA isolationen_US
dc.subjectsignal transductionen_US
dc.subjectsix minute walk testen_US
dc.subjectWorld Health Organization functional classen_US
dc.subjectgeneticsen_US
dc.subjecthypoxiaen_US
dc.subjectmetabolismen_US
dc.subjectAdenosine Diphosphate Riboseen_US
dc.subjectApelinen_US
dc.subjectHumansen_US
dc.subjectHypertension, Pulmonaryen_US
dc.subjectHypoxiaen_US
dc.subjectKynurenineen_US
dc.subjectMicroRNAsen_US
dc.subjectPoly(ADP-ribose) Polymerase Inhibitorsen_US
dc.subjectPoly(ADP-ribose) Polymerasesen_US
dc.subjectProspective Studiesen_US
dc.subjectRNA, Messengeren_US
dc.titleKynurenine-PARP-1 Link Mediated by MicroRNA 210 May Be Dysregulated in Pulmonary Hypertension [Article]en_US
dc.typeArticleen_US
dc.identifier.volume26en_US
dc.identifier.issue5en_US
dc.identifier.startpage388en_US
dc.identifier.endpage393en_US
dc.identifier.doi10.5152/AnatolJCardiol.2021.861-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid57203067698-
dc.authorscopusid6507192665-
dc.authorscopusid56499294100-
dc.authorscopusid24066601700-
dc.authorscopusid56345836900-
dc.identifier.pmid35552175en_US
dc.identifier.scopus2-s2.0-85130067787en_US
dc.identifier.trdizinid521492en_US
dc.identifier.wosWOS:000801154700007en_US
dc.identifier.scopusqualityQ3-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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