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https://hdl.handle.net/11499/47830
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DC Field | Value | Language |
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dc.contributor.author | Akgün, Alperen Emre | - |
dc.contributor.author | Yaylalı, Yalın Tolga | - |
dc.contributor.author | Seçme, Mücahit | - |
dc.contributor.author | Dodurga, Yavuz | - |
dc.contributor.author | Şenol, Hande | - |
dc.date.accessioned | 2023-01-09T21:30:16Z | - |
dc.date.available | 2023-01-09T21:30:16Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 2149-2263 | - |
dc.identifier.uri | https://doi.org/10.5152/AnatolJCardiol.2021.861 | - |
dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/521492 | - |
dc.identifier.uri | https://hdl.handle.net/11499/47830 | - |
dc.description.abstract | Background: Dysregulation of microRNAs is associated with pulmonary hypertension. The present study aimed to determine the alterations in microRNA and microRNA expressions and their role in signaling pathways and investigate the relationship with serum levels of apelin, kynurenine, and endocan in pulmonary hypertension. Methods: The study design was prospective and single-centered. The study included 32 consecutive treatment-naive patients with precapillary pulmonary hypertension and 55 age and sex-matched healthy controls. All subjects underwent right heart catheterization. mRNA expressions of hypoxia-inducible factor-1 alpha, hypoxia-inducible factor-2 alpha, signal transducer and activator of transcription-3, fibroblast growth factor-2, fibroblast growth factor receptor-1, and poly-ADP-ribose polymerase-1 and microRNA expressions of miRNA-210, miRNA-130a, miRNA-424, miRNA-204, and miRNA-223 were determined by RT-PCR. Concentrations of kynurenine, apelin, and endocan were analyzed by ELISA. Results: mRNA expressions of hypoxia-inducible factor-2 alpha, signal transducer and activator of transcription-33, and FGF-2 were increased; miRNA-210 and miRNA-130a were increased; miRNA-223 and miRNA-204 were decreased in pulmonary hypertension. Apelin and kynurenine concentrations were decreased in pulmonary hypertension. There were positive correlations: hypoxia-inducible factor-2 alpha-miRNA-424, ApelinmiRNA-424, kynurenine-miRNA-210, signal transducer and activator of transcription-3-PVR, miRNA-210-right atrial pressure, and kynurenine-right atrial pressure. There were negative correlations: poly-ADP-ribose polymerase-1-miRNA-210 and poly-ADP-ribose polymerase-1-right atrial pressure. On multiple logistic regression analyses, miRNA-130a and Apelin were independent risk factors for PH. Conclusions: We report a novel relationship between the kynurenine and poly-ADPribose polymerase-1 signaling pathways that could be mediated by miRNA-210. We also report a connection between the Apelin and hypoxia-inducible factor-2 alpha signaling pathways that could be mediated by miRNA-424. Reduced levels of Apelin and elevated levels of miRNA-130a are associated with pulmonary hypertension. We also find that elevated levels of signal transducer and activator of transcription-3, miRNA-210, and kynurenine and reduced levels of poly-ADP-ribose polymerase-1 correlate with more severe hemodynamics. © 2022 Turkish Society of Cardiology. All rights reserved. | en_US |
dc.description.sponsorship | 2018TIPF023 | en_US |
dc.description.sponsorship | Funding: The authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation. A. Akgün and Y.T. Yaylalı contributed equally to this work. This study was supported by Pamukkale University Scientific Research Projects Coordination Unit through project number 2018TIPF023. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Turkish Society of Cardiology | en_US |
dc.relation.ispartof | Anatolian Journal of Cardiology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | kynurenine | en_US |
dc.subject | MicroRNA | en_US |
dc.subject | poly-ADP-ribose polymerase-1 | en_US |
dc.subject | pulmonary hypertension | en_US |
dc.subject | apelin | en_US |
dc.subject | endocan | en_US |
dc.subject | fibroblast growth factor 2 | en_US |
dc.subject | fibroblast growth factor receptor 1 | en_US |
dc.subject | hypoxia inducible factor 1alpha | en_US |
dc.subject | hypoxia inducible factor 2alpha | en_US |
dc.subject | kynurenine | en_US |
dc.subject | membrane protein | en_US |
dc.subject | microRNA 130a | en_US |
dc.subject | microRNA 204 | en_US |
dc.subject | microRNA 210 | en_US |
dc.subject | microRNA 223 | en_US |
dc.subject | microRNA 424 | en_US |
dc.subject | nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1 | en_US |
dc.subject | STAT3 protein | en_US |
dc.subject | unclassified drug | en_US |
dc.subject | adenosine diphosphate ribose | en_US |
dc.subject | apelin | en_US |
dc.subject | kynurenine | en_US |
dc.subject | messenger RNA | en_US |
dc.subject | microRNA | en_US |
dc.subject | MIRN204 microRNA, human | en_US |
dc.subject | MIRN210 microRNA, human | en_US |
dc.subject | nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase | en_US |
dc.subject | nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor | en_US |
dc.subject | adult | en_US |
dc.subject | Article | en_US |
dc.subject | assessment of humans | en_US |
dc.subject | cardiac index | en_US |
dc.subject | chronic thromboembolic pulmonary hypertension | en_US |
dc.subject | clinical article | en_US |
dc.subject | clinical assessment | en_US |
dc.subject | clinical feature | en_US |
dc.subject | controlled study | en_US |
dc.subject | enzyme linked immunosorbent assay | en_US |
dc.subject | female | en_US |
dc.subject | heart catheterization | en_US |
dc.subject | heart hemodynamics | en_US |
dc.subject | heart right atrium pressure | en_US |
dc.subject | human | en_US |
dc.subject | lung vascular resistance | en_US |
dc.subject | male | en_US |
dc.subject | mRNA expression level | en_US |
dc.subject | outcome assessment | en_US |
dc.subject | prospective study | en_US |
dc.subject | protein expression | en_US |
dc.subject | pulmonary hypertension | en_US |
dc.subject | reverse transcription polymerase chain reaction | en_US |
dc.subject | RNA isolation | en_US |
dc.subject | signal transduction | en_US |
dc.subject | six minute walk test | en_US |
dc.subject | World Health Organization functional class | en_US |
dc.subject | genetics | en_US |
dc.subject | hypoxia | en_US |
dc.subject | metabolism | en_US |
dc.subject | Adenosine Diphosphate Ribose | en_US |
dc.subject | Apelin | en_US |
dc.subject | Humans | en_US |
dc.subject | Hypertension, Pulmonary | en_US |
dc.subject | Hypoxia | en_US |
dc.subject | Kynurenine | en_US |
dc.subject | MicroRNAs | en_US |
dc.subject | Poly(ADP-ribose) Polymerase Inhibitors | en_US |
dc.subject | Poly(ADP-ribose) Polymerases | en_US |
dc.subject | Prospective Studies | en_US |
dc.subject | RNA, Messenger | en_US |
dc.title | Kynurenine-PARP-1 Link Mediated by MicroRNA 210 May Be Dysregulated in Pulmonary Hypertension [Article] | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 26 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 388 | en_US |
dc.identifier.endpage | 393 | en_US |
dc.identifier.doi | 10.5152/AnatolJCardiol.2021.861 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57203067698 | - |
dc.authorscopusid | 6507192665 | - |
dc.authorscopusid | 56499294100 | - |
dc.authorscopusid | 24066601700 | - |
dc.authorscopusid | 56345836900 | - |
dc.identifier.pmid | 35552175 | en_US |
dc.identifier.scopus | 2-s2.0-85130067787 | en_US |
dc.identifier.trdizinid | 521492 | en_US |
dc.identifier.wos | WOS:000801154700007 | en_US |
dc.identifier.scopusquality | Q3 | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairetype | Article | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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File | Size | Format | |
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ajc-26-5-388.pdf | 1.33 MB | Adobe PDF | View/Open |
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