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Title: | Neuroprotective effect of carvacrol in an experimental cerebral ischemia and reperfusion rat model | Authors: | Başaran M. Öztanir M.N. Çıftçı O. Başak Türkmen N. Akyuva Y. Önder A. |
Keywords: | carvacrol CAT CMC GSH GSH-Px IL-1? IL-4 ischemia reperfusion SOD TBARS TNF-? carboxymethylcellulose carvacrol catalase glutathione interleukin 1beta interleukin 4 superoxide dismutase thiobarbituric acid reactive substance tumor necrosis factor animal experiment animal model animal tissue antiinflammatory activity antioxidant activity Article carotid artery injury cerebral ischemia reperfusion injury controlled study drug effect experimental cerebral ischemia male neuroprotection nonhuman rat rat model |
Publisher: | Ondokuz Mayis Universitesi | Abstract: | The Neuroprotective effect of carvacrol, which has anti-inflammatory and antioxidant effects, on infarcted cerebral tissue is present in literature, but this contribution was not sufficiently clarified in terms of biochemistry. It is aimed to investigate the effect of orally administered carvacrol on plasma and intraparenchymal levels of TBARS, GSH, SOD, CAT, GSH-Px, IL-1?, IL-4, and TNF-? after the formation of global ischemia in cerebral tissue. Four groups were formed, each containing ten Wistar albino rats. After anesthesia and analgesia, bilateral carotid communis arteries of rats in the first two groups were clamped for 15 minutes with aneurysm clips. Oral 50 mg/kg/day carvacrol was administered for 15 days to the first group (I/R+CRV) of these two groups in which cerebral ischemia-reperfusion (I/R) was established. On the other hand, %0,01 carboxymethylcellulose (CMC), which is a solvent of carvacrol, at a same volume of first group was administered orally for the same duration to the other group in which also I/R was established (I/R+CMC). In the other two groups in which ischemia was not induced, only carotid artery dissections were made and sutured again. In these two groups, 50 mg/kg/day of carvacrol was administered to the first group (CRV). The Same dose of CMC was administered to the second group (control group). After all these treatments, plasma was collected, and brain tissue was dissected from all groups at the end of the 15th day. Carvacrol can be included in the possible treatment regimen of cerebral stroke with the help of other studies that can be supported on this topic. © 2022 Ondokuz Mayis Universitesi. All rights reserved. | URI: | https://doi.org/10.52142/omujecm.39.2.28 https://hdl.handle.net/11499/47842 |
ISSN: | 1309-4483 |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu |
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