A Case of Gastrointestinal Surgery-Related Pellagra

Abstract

Pellagra is a multisystemic disease caused by niacin deficiency and characterized by diarrhea, dementia, dermatitis and, death. The lesions appear as hyperkeratotic, sharply demarcated erythematous plaques and bullae symmetrically distributed in photo-exposed areas. Poverty, hunger, anorexia and, alcoholism are among the most common reasons for diminished gastrointestinal (GIS) niacin uptake. Also rarely, GIS operations may end up with niacin deficiency. A 65-year-old man applied to our clinic with complaints of blisters in his feet, discoloration in his face and hands along with a mood alteration. The lesions were violaceous and sharply demarcated in a photosensitive distribution. He had a history of GIS surgery and he was diagnosed with pellagra disease by clinicopathologic evaluation. Pellagra responds excellently to the treatment, but it has a fatal course when overlooked. Herein, we present this case to underline the importance of keeping in mind that pellagra may develop after gastrointestinal surgeries. © 2021 by Türkiye Klinikleri.