Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4785
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dc.contributor.authorŞentürk, Ü.K.-
dc.contributor.authorGündüz, F.-
dc.contributor.authorKuru, O.-
dc.contributor.authorKoçer, G.-
dc.contributor.authorÖzkaya, Y.G.-
dc.contributor.authorYeşilkaya, A.-
dc.contributor.authorBor-Küçükatay, M.-
dc.date.accessioned2019-08-16T11:37:15Z-
dc.date.available2019-08-16T11:37:15Z-
dc.date.issued2005-
dc.identifier.issn8750-7587-
dc.identifier.urihttps://hdl.handle.net/11499/4785-
dc.identifier.urihttps://doi.org/10.1152/japplphysiol.01392.2004-
dc.description.abstractIntravascular hemolysis is one of the most emphasized mechanisms for destruction of erythrocytes during and after physical activity. Exercise-induced oxidative stress has been proposed among the different factors for explaining exercise-induced hemolysis. The validity of oxidative stress following exhaustive cycling exercise on erythrocyte damage was investigated in sedentary and trained subjects before and after antioxidant vitamin treatment (A, C, and E) for 2 mo. Exercise induced a significant increase in thiobarbituric acid-reactive substance and protein carbonyl content levels in sedentary subjects and resulted in an increase of osmotic fragility and decrease in deformability of erythrocytes, accompanied by signs for intravascular hemolysis (increase in plasma hemoglobin concentration and decrease in haptoglobulin levels). Administration of antioxidant vitamins for 2 mo prevented exercise-induced oxidative stress (thiobarbituric acid-reactive substance, protein carbonyl content) and deleterious effects of exhaustive exercise on erythrocytes in sedentary subjects. Trained subjects' erythrocyte responses to exercise were different from those of sedentary subjects before antioxidant vitamin treatment. Osmotic fragility and deformability of erythrocytes, plasma hemoglobin concentration, and haptoglobulin levels were not changed after exercise, although the increased oxidative stress was observed in trained subjects. After antioxidant vitamin treatment, functional and structural parameters of erythrocytes were not altered in the trained group, but exercise-induced oxidative stress was prevented. Increased percentage of young erythrocyte populations was determined in trained subjects by density separation of erythrocytes. These findings suggest that the exercise-induced oxidative stress may contribute to exercise-induced hemolysis in sedentary humans. Copyright © 2005 the American Physiological Society.en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Applied Physiologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDeformabilityen_US
dc.subjectOsmotic fragilityen_US
dc.subjectSports anemiaen_US
dc.subjectantioxidanten_US
dc.subjectcarbonyl derivativeen_US
dc.subjectcatalaseen_US
dc.subjectglutathione peroxidaseen_US
dc.subjecthaptoglobinen_US
dc.subjecthemoglobinen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectthiobarbituric acid reactive substanceen_US
dc.subjectvitaminen_US
dc.subjectadulten_US
dc.subjectanemiaen_US
dc.subjectarticleen_US
dc.subjectcell populationen_US
dc.subjectcontrolled studyen_US
dc.subjectcyclingen_US
dc.subjecterythrocyte deformabilityen_US
dc.subjecterythrocyte fragilityen_US
dc.subjecterythrocyte structureen_US
dc.subjectexerciseen_US
dc.subjectexhaustionen_US
dc.subjecthemoglobin determinationen_US
dc.subjecthumanen_US
dc.subjecthuman experimenten_US
dc.subjectintravascular hemolysisen_US
dc.subjectmaleen_US
dc.subjectnormal humanen_US
dc.subjectosmotic fragilityen_US
dc.subjectoxidative stressen_US
dc.subjectpathophysiologyen_US
dc.subjectphysical activityen_US
dc.subjectpriority journalen_US
dc.subjectprotein contenten_US
dc.subjectsittingen_US
dc.subjecttrainingen_US
dc.subjecttreatment outcomeen_US
dc.subjectAdulten_US
dc.subjectAntioxidantsen_US
dc.subjectAscorbic Aciden_US
dc.subjectBicyclingen_US
dc.subjectErythrocyte Deformabilityen_US
dc.subjectErythrocytesen_US
dc.subjectExerciseen_US
dc.subjectHemolysisen_US
dc.subjectHumansen_US
dc.subjectLife Styleen_US
dc.subjectMaleen_US
dc.subjectOsmotic Fragilityen_US
dc.subjectOxidative Stressen_US
dc.subjectOxidoreductasesen_US
dc.subjectPhysical Education and Trainingen_US
dc.subjectThiobarbituric Acid Reactive Substancesen_US
dc.subjectVitamin Aen_US
dc.subjectVitamin Een_US
dc.titleExercise-induced oxidative stress leads hemolysis in sedentary but not trained humansen_US
dc.typeArticleen_US
dc.identifier.volume99en_US
dc.identifier.issue4en_US
dc.identifier.startpage1434-
dc.identifier.startpage1434en_US
dc.identifier.endpage1441en_US
dc.identifier.doi10.1152/japplphysiol.01392.2004-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid15976356en_US
dc.identifier.scopus2-s2.0-29544442618en_US
dc.identifier.wosWOS:000232276800029en_US
dc.identifier.scopusqualityQ1-
dc.ownerPamukkale_University-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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