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https://hdl.handle.net/11499/47867
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DC Field | Value | Language |
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dc.contributor.author | Akin A.T. | - |
dc.contributor.author | Kaymak E. | - |
dc.contributor.author | Öztürk E. | - |
dc.contributor.author | Ceylan T. | - |
dc.contributor.author | Yalçin B. | - |
dc.contributor.author | Başaran K.E. | - |
dc.contributor.author | Karabulut D. | - |
dc.contributor.author | Doğanyiğit, Züleyha | - |
dc.contributor.author | Özdamar, Saim | - |
dc.contributor.author | Yakan, Birkan | - |
dc.date.accessioned | 2023-01-09T21:30:30Z | - |
dc.date.available | 2023-01-09T21:30:30Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 0377-9777 | - |
dc.identifier.uri | https://doi.org/10.5505/TurkHijyen.2022.78476 | - |
dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/1118991 | - |
dc.identifier.uri | https://hdl.handle.net/11499/47867 | - |
dc.description.abstract | Objective: Hypoxia has an important role in the disruption of intestinal mucosal integrity because of inflammation and apoptosis induced by inflammatory cytokines such as TNF-a (Tumor necrosis factor-alpha), IL-6 and IFN-y, and apoptotic regulatory proteins. Chloroquine (CLQ) is a drug used in the novel coronavirus disease (COVID-19) and is widely used for the treatment of many inflammatory diseases such as malaria and rheumatoid arthritis. In this study, we aimed to reduce the destructive effects of hypoxia-induced inflammation and apoptosis in the intestinal mucosa of rats with CLQ applications. Methods: For this purpose, a total of 24 Wistar Albino rats were randomly divided into three groups; Group I: Control group (n=8), Group II: Hypoxia (n=8) and Group III: Hypoxia + CLQ (n=8). The control group was housed in plexiglass cages to keep the oxygen levels at 10% levels for 28 days, while the hypoxia and hypoxia+CLQ groups were housed in a normal atmospheric environment (21% O2), and the hypoxia+CLQ group was administered CLQ at a dose of 50 mg/kg every day for 28 days. At the end of the experiment, the intestinal tissues of the experimental animals, were extracted under the anesthesia and they were sacrificed. Results: As a result of histopathological evaluations, it was determined that CLQ applications showed healing properties on the histopathological effects induced by hypoxia in the intestine. While an increase in TNF-? expression was observed in the hypoxia group, a statistically significant decrease was detected in the hypoxia+CLQ group. In addition, Bax expression was found to be statistically significantly lower in the hypoxia+CLQ group when compared to the hypoxia group. On the contrary, it was observed that Bcl-2 expression was statistically significantly increased in the hypoxia+CLQ group compared to the Hypoxia group. Conclusion: We observed that hypoxia causes significant damage to the intestinal mucosa and triggers a severe inflammation that drives cells to apoptosis. Considering the curative effects of chloroquine on the intestinal mucosa, we suggest that this anti-inflammatory drug has a potential to use clinically to alleviate the deleterious effects of hypoxia in the intestine. © 2022. All Rights Reserved. | en_US |
dc.description.sponsorship | TDK-2018-8099 | en_US |
dc.description.sponsorship | This study was supported by Erciyes University Scientific Research Projects Commission with the Project code number TDK-2018-8099. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Refik Saydam National Public Health Agency (RSNPHA) | en_US |
dc.relation.ispartof | Turk Hijyen ve Deneysel Biyoloji Dergisi | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Apoptozis | en_US |
dc.subject | bağırsak | en_US |
dc.subject | chloroquine | en_US |
dc.subject | hipoksi | en_US |
dc.subject | hypoxia | en_US |
dc.subject | intestine | en_US |
dc.subject | klorokuin | en_US |
dc.subject | TNF-? | en_US |
dc.subject | TNF-? | en_US |
dc.title | Mitigative effects of chloroquine treatment against hypoxia-induced intestinal injury: a histological and immunohistochemical study | en_US |
dc.title.alternative | Hipoksiye bağlı bağırsak hasarına karşı klorokin tedavisinin hafifletici etkileri: histolojik ve immünohistokimyasal bir çalışma | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 79 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 59 | en_US |
dc.identifier.endpage | 70 | en_US |
dc.identifier.doi | 10.5505/TurkHijyen.2022.78476 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57196939064 | - |
dc.authorscopusid | 57188632370 | - |
dc.authorscopusid | 36131874700 | - |
dc.authorscopusid | 57221313801 | - |
dc.authorscopusid | 56446475600 | - |
dc.authorscopusid | 57050249800 | - |
dc.authorscopusid | 56595045000 | - |
dc.identifier.scopus | 2-s2.0-85129815407 | en_US |
dc.identifier.trdizinid | 1118991 | en_US |
dc.identifier.scopusquality | Q4 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 12.02. Archaeology | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection |
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File | Size | Format | |
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Mitigative effects of chloroquine.pdf | 3.01 MB | Adobe PDF | View/Open |
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