Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47867
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAkin A.T.-
dc.contributor.authorKaymak E.-
dc.contributor.authorÖztürk E.-
dc.contributor.authorCeylan T.-
dc.contributor.authorYalçin B.-
dc.contributor.authorBaşaran K.E.-
dc.contributor.authorKarabulut D.-
dc.contributor.authorDoğanyiğit, Züleyha-
dc.contributor.authorÖzdamar, Saim-
dc.contributor.authorYakan, Birkan-
dc.date.accessioned2023-01-09T21:30:30Z-
dc.date.available2023-01-09T21:30:30Z-
dc.date.issued2022-
dc.identifier.issn0377-9777-
dc.identifier.urihttps://doi.org/10.5505/TurkHijyen.2022.78476-
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1118991-
dc.identifier.urihttps://hdl.handle.net/11499/47867-
dc.description.abstractObjective: Hypoxia has an important role in the disruption of intestinal mucosal integrity because of inflammation and apoptosis induced by inflammatory cytokines such as TNF-a (Tumor necrosis factor-alpha), IL-6 and IFN-y, and apoptotic regulatory proteins. Chloroquine (CLQ) is a drug used in the novel coronavirus disease (COVID-19) and is widely used for the treatment of many inflammatory diseases such as malaria and rheumatoid arthritis. In this study, we aimed to reduce the destructive effects of hypoxia-induced inflammation and apoptosis in the intestinal mucosa of rats with CLQ applications. Methods: For this purpose, a total of 24 Wistar Albino rats were randomly divided into three groups; Group I: Control group (n=8), Group II: Hypoxia (n=8) and Group III: Hypoxia + CLQ (n=8). The control group was housed in plexiglass cages to keep the oxygen levels at 10% levels for 28 days, while the hypoxia and hypoxia+CLQ groups were housed in a normal atmospheric environment (21% O2), and the hypoxia+CLQ group was administered CLQ at a dose of 50 mg/kg every day for 28 days. At the end of the experiment, the intestinal tissues of the experimental animals, were extracted under the anesthesia and they were sacrificed. Results: As a result of histopathological evaluations, it was determined that CLQ applications showed healing properties on the histopathological effects induced by hypoxia in the intestine. While an increase in TNF-? expression was observed in the hypoxia group, a statistically significant decrease was detected in the hypoxia+CLQ group. In addition, Bax expression was found to be statistically significantly lower in the hypoxia+CLQ group when compared to the hypoxia group. On the contrary, it was observed that Bcl-2 expression was statistically significantly increased in the hypoxia+CLQ group compared to the Hypoxia group. Conclusion: We observed that hypoxia causes significant damage to the intestinal mucosa and triggers a severe inflammation that drives cells to apoptosis. Considering the curative effects of chloroquine on the intestinal mucosa, we suggest that this anti-inflammatory drug has a potential to use clinically to alleviate the deleterious effects of hypoxia in the intestine. © 2022. All Rights Reserved.en_US
dc.description.sponsorshipTDK-2018-8099en_US
dc.description.sponsorshipThis study was supported by Erciyes University Scientific Research Projects Commission with the Project code number TDK-2018-8099.en_US
dc.language.isoenen_US
dc.publisherRefik Saydam National Public Health Agency (RSNPHA)en_US
dc.relation.ispartofTurk Hijyen ve Deneysel Biyoloji Dergisien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectApoptozisen_US
dc.subjectbağırsaken_US
dc.subjectchloroquineen_US
dc.subjecthipoksien_US
dc.subjecthypoxiaen_US
dc.subjectintestineen_US
dc.subjectklorokuinen_US
dc.subjectTNF-?en_US
dc.subjectTNF-?en_US
dc.titleMitigative effects of chloroquine treatment against hypoxia-induced intestinal injury: a histological and immunohistochemical studyen_US
dc.title.alternativeHipoksiye bağlı bağırsak hasarına karşı klorokin tedavisinin hafifletici etkileri: histolojik ve immünohistokimyasal bir çalışmaen_US
dc.typeArticleen_US
dc.identifier.volume79en_US
dc.identifier.issue1en_US
dc.identifier.startpage59en_US
dc.identifier.endpage70en_US
dc.identifier.doi10.5505/TurkHijyen.2022.78476-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid57196939064-
dc.authorscopusid57188632370-
dc.authorscopusid36131874700-
dc.authorscopusid57221313801-
dc.authorscopusid56446475600-
dc.authorscopusid57050249800-
dc.authorscopusid56595045000-
dc.identifier.scopus2-s2.0-85129815407en_US
dc.identifier.trdizinid1118991en_US
dc.identifier.scopusqualityQ4-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.cerifentitytypePublications-
crisitem.author.dept12.02. Archaeology-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
Files in This Item:
File SizeFormat 
Mitigative effects of chloroquine.pdf3.01 MBAdobe PDFView/Open
Show simple item record



CORE Recommender
Sorry the service is unavailable at the moment. Please try again later.

Page view(s)

60
checked on Aug 24, 2024

Download(s)

10
checked on Aug 24, 2024

Google ScholarTM

Check





Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.