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https://hdl.handle.net/11499/47899
Title: | Relationships among Bone Metabolic Markers, Body Fat Composition and Carotid Intima–Media Thickness in Premenopausal Obese Women | Authors: | Yaylalia G.F. Dedeoglu O. Topsakal S. Herek D. Senol H. |
Keywords: | body fat composition carotid intima-media thickness obesity osteocalcin premenopausal women biological marker osteocalcin adipose tissue adolescent adult arterial wall thickness blood body fat distribution bone case control study diagnostic imaging echography female human metabolism middle aged obesity premenopause prospective study young adult Adipose Tissue Adolescent Adult Biomarkers Body Fat Distribution Bone and Bones Carotid Intima-Media Thickness Case-Control Studies Female Humans Middle Aged Obesity Osteocalcin Premenopause Prospective Studies Ultrasonography Young Adult |
Publisher: | Okayama University | Abstract: | Osteocalcin (OC) is inversely related to body fat distribution and fasting glucose levels. We sought to observe the effect of OC on fat distribution and subclinical atherosclerosis as measured by carotid intima-media thickness (CIMT) in premenopausal obese women. In this prospective observational study, totally, 73 premenopausal obese women (aged 17-55 years) and 53 healthy women (aged 20-50 years) with normal weight were included as controls. Anthropometric measurements, total fat and fat ratio, insulin, fasting blood glucose, and OC levels were estimated. Ultrasonography was used to assess fat distribution, and fat thickness was measured in 4 regions. Subcutaneous fat (SCF), visceral fat (VF), and preperitoneal fat (PPF) thicknesses were considerably higher in obese subjects (p< 0.01) than healthy controls, while OC levels were significantly lower. No correlation was observed between OC levels and SCF, VF, or PPF. In a multiple regression analysis, OC was significantly positively associated with SCF (p=0.04, Beta=0.284). No associations were observed between OC levels and VF, PPF, or CIMT. A significant association was observed between parathyroid hormone (PTH) and VF (p=0.021, Beta=0.284), and vitamin D levels were inversely associated with VF (p=0.002, r=?0.366). OC levels were lower in premenopausal obese women than normal-weight healthy controls, but OC exhibited no correlation with VF or PPF, and only a weak positive association with SCF. Additionally, VF was positively correlated with PTH and inversely correlated with vitamin D. These results suggest that OC may be an early indicator of lipid accumulation in te subcutaneous area and development of atherosclerosis. © 2021, Acta Medica Okayama. All Rights Reserved. | URI: | https://hdl.handle.net/11499/47899 | ISSN: | 0386-300X |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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