Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4804
Title: An atypical case of POEMS syndrome with IgG kappa M protein and end stage renal failure
Authors: Dursun, Belda
Artac, M.
Varan, H.I.
Akkaya, B.K.
Karpuzoglu, G.
Suleymanlar, G.
Keywords: IgG kappa monoclonal protein
POEMS syndrome
Renal failure
cyclophosphamide
immunoglobulin
immunoglobulin kappa chain
immunoglobulin lambda chain
levothyroxine
M protein
methylprednisolone
prednisolone
adult
article
bone lesion
cachexia
case report
chronic disease
clinical feature
demyelinating neuropathy
drug dose regimen
fatality
gynecomastia
hematuria
hemodialysis
hepatosplenomegaly
human
human tissue
hypothyroidism
kidney dysfunction
kidney failure
male
monoclonal immunoglobulinemia
paraproteinemia
pathogenesis
plasma cell dyscrasia
plasmapheresis
proteinuria
rare disease
skin defect
Cachexia
Fatal Outcome
Humans
Immunoglobulin G
Kidney Failure, Chronic
Male
Middle Aged
POEMS Syndrome
Abstract: POEMS syndrome is a rare plasma cell dyscrasia which is characterized by small amounts of monoclonal protein, and a multisystem complex manifested by various combinations of polyneuropathy, organomegaly, endocrinopathy and skin changes. Here, we presented an atypical case of POEMS syndrome with IgG kappa monoclonal protein, chronic demyelinating polyneuropathy, hepatosplenomegaly, hypothyroidism, gynecomastia and severe renal impairment. The finding of IgG kappa type of monoclonal protein in our patient was interesting because the majority of cases were reported to have lambda light chain. Also, the absence of typical skin and bone lesions were atypical. Though speculative, these atypical features may account for the unusual presentation of this case. Our patient rapidly progressed to end-stage renal failure and died of cachexia. Renal involvement in POEMS syndrome is rare but may show substantial clinical and pathological variations. Proteinuria, hematuria, renal dysfunction and renal failure requiring hemodialysis can be seen. The pathogenesis of renal dysfunction is unclear. As a conclusion, POEMS syndrome may present with diverse clinicopathologic manifestations. In this syndrome, renal involvement may lead to end stage renal failure and the course may be fatal due to severe polyneuropathy and wasting. © Springer 2005.
URI: https://hdl.handle.net/11499/4804
https://doi.org/10.1007/s11255-004-0008-0
ISSN: 0301-1623
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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