Chiral Separations by Capillary Electrophoresis and Related Techniques withDifferent Chiral Selectors: A Review

Abstract

Recognition mechanism and enantiomerically separations of the chiral compounds are subjects that always stimulate the great interest of researchers in pharmacology and natural sciences, who are interested in finding solutions for both analytical purity and preparative purposes. Capillary Electrophoresis has become one of the most important analytical approaches for enantiomeric separations due to its superior properties, such as high resolution and high efficiency of chiral selectors. In this field, where researchers continue to be interested, the distinctions continue to develop day by day, with the introduction of new techniques developed on the basis of Capillary Electrophoresis philosophy in parallel with the development process of technology, as well as the chiral selectors of many different forms. In this review, besides some descriptive theoretical information about capillary electrophoresis and the techniques associated with it, studies on chiral separations using different chiral selectors or different chiral additives, such as molecularly imprinted polymers, cyclodextrins, Metal-organic frameworks, ionic liquids, nanoparticles and monoliths in the last nearly 10 years (2010-2020) were examined.