Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4821
Title: QT dispersion and left ventricular hypertrophy in athletes: Relationship with angiotensin-converting enzyme I/D polymorphism
Authors: Tanrıverdi, Halil
Kaftan, Havane Asuman
Evrengül, Harun
Dursunoğlu, Dursun
Turgut, Günfer
Kılıç, Mustafa
Keywords: ACE I/D polymorphism
Athlete
QT dispersion
Ventricular hypertrophy
dipeptidyl carboxypeptidase
DNA
adult
article
athlete
controlled study
echocardiography
electrocardiogram
female
genetic polymorphism
genotype
heart left ventricle hypertrophy
human
major clinical study
male
training
Adult
Case-Control Studies
Echocardiography
Electrocardiography
Exercise
Female
Genotype
Heart Ventricles
Humans
Hypertrophy, Left Ventricular
Male
Peptidyl-Dipeptidase A
Physical Endurance
Polymorphism, Genetic
Regression Analysis
Sports
Abstract: Background - QT dispersion (QTd) is a measure of inhomogeneous repolarization of myocardium and is used as an indicator of arrhythmogenicity. QTd is increased in myocardial hypertrophy secondary to systemic hypertension. The relation between left ventricular (LV) enlargement in endurance trained subjects and QTd is unknown. The cloning of the angiotensin-converting enzyme (ACE) gene has made it possible to identify a deletion (D)-insertion (I) polymorphism that appears to affect the level of serum ACE activity. The aim of this study was to assess whether physiologic left ventricular hypertrophy as a result of physical training is associated with an increased QT length or dispersion depending on ACE I/D polymorphism. Methods - 56 endurance athletes and 46 sedentary subjects were included in this study, and they underwent both complete echocardiographic and electrocardiographic examination, the QT interval was measured manually as an average based on a 12-lead ECG. We also analysed ACE I and D allele frequencies in all patients. Results - Athletes had a significantly increased LV mass (235.1 ± 68.5 g vs. 144.9 ± 44.5 g, p < 0.001) and corrected QTd (QTcd) (55.5 ± 18.1 ms vs. 42.9 ± 17.2 ms, p < 0.001) in comparison to control subjects. There was a positive correlation between left ventricular mass index and QTcd in athletes (r = 0.3, p = 0.024). Left ventricular mass and mass index in ACE DD, DI and II genotypes were significantly different (p < 0.001). QTcd was significantly different between ACE DD (63.2 ± 12.8 ms) and ACE II (44.9 ± 17.6 ms) genotypes in athletes (p < 0.05). Conclusion - These data show that myocardial hypertrophy induced by exercise training might be associated with increased QTd as observed in systemic hypertension and might be affected by ACE I/D polymorphism.
URI: https://hdl.handle.net/11499/4821
https://doi.org/10.2143/AC.60.4.2004987
ISSN: 0001-5385
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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