The effectiveness of antioxidant drugs such as N-acetylcysteine and Ozone on the stasis zone

Abstract

Purpose: Stasis zone, the zone around the coagulation zone, is important for the prevention necrosis in burns.Various drugs were studied in literature to prevent necrosis in stasis zone. The previous researches haveshown the effectiveness of Nacetylcysteine treatment on both remote organs and local side in thermal injury.Demonstration of the effectiveness of N acetylcysteine and Ozone on stasis zone prevention in thermal injurywas the goal of this study.Methods: For this purpose, 24 4-month-old Wistar albino type female rats weighing 200±20 g were used in thestudy. Compound burning model was made in these rats. Next, the compound was applied to the combustionmodel to compare the effectiveness of N-acetylcysteine and Ozone. To identfy histopathological destructionseverity a scoring method was applied. Malondialdhyede (MDA), Glutathione Peroxidase (GPx), Superoksiddismutase (SOD), and catalase (CAT) levels were analyzed in serum samples of the rats to find out thealterations in the balance between oxidatitaion and antioxidation system.Results: While the highest MDA levels were observed in group I, the decrease was significant in group II and III(p=0.03 and p<0.02). SOD levels were significantly higher in group III compared to group II (p<0.05). CAT levelswere higher in group II and III than group I (p<0.001, p<0.001). GPx levels were higher in group II (p<0.001), andgroup III (p<0.001). Histopathological scores were lower in group III than group I (p=0.001).Conclusion: This study showed that both Ozone and N-acetylcysteine are effective agents in rescuing thestasis site. It was also concluded that Ozone might be more beneficial than N-acetylcysteine.