Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/48533
Title: | The XPD/ERCC2, RAD51 and hOGG1 Gene Polymorphisms in Turkish Patients with Advanced-Stage Gastric Cancer | Authors: | Tanrıverdi, Özgür Gököz Doğu, Gamze Kargı, Ayşegül Demiray, Aydın Yapar Taşköylü, Burcu Demiray, Atike Gökçen Yaren, Arzu Özlü, Can Ergin, Ahmet Akça, Hakan |
Abstract: | In this study, we evaluated the effects of XPD/ERCC2, RAD51 and hOGG1 gene polymorphisms on prognosis in Turkish patients with advanced gastric cancer. A total of 31 gastric cancer patients with locally inoperable or distant metastasis and performance status of 0–2 and 29 healthy volunteers as the control group were enrolled in this study. DNA was isolated from serum and then single nucleotide gene polymorphism analyses were done by MassARRAY Analyzer 4 System [Sequenom]. Statistical significance of the observed genotype frequencies was evaluated according to Hardy–Weinberg rule compared to the expected genotype frequencies. Median age was 68 years: 74% male, 26% female in the study group. We determined the XPD/ERCC2 Asp312Asn [rs1799793] single nucleotide gene polymorphism G23591A, RAD51 [rs1801320] single nucleotide gene polymorphism G135C and hOGG1 Ser 326 Cys [rs1052133] single nucleotide gene polymorphism. We could not find any significant association between the genotypes and prognosis in Turkish patients with gastric cancer. | URI: | https://doi.org/10.47572/muskutd.676049 https://search.trdizin.gov.tr/yayin/detay/470864 http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/48533 |
ISSN: | 2148-8118 2618-6020 |
Appears in Collections: | Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection |
Files in This Item:
File | Size | Format | |
---|---|---|---|
document (3).pdf | 421.65 kB | Adobe PDF | View/Open |
CORE Recommender
Page view(s)
76
checked on Aug 24, 2024
Download(s)
12
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.