Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4859
Title: Malign cystic glucagonoma presented with diabetic ketoacidosis: Case report with an update
Authors: Fenkci, S.M.
Yaylalı, Güzin Fidan
Sermez, Y.
Akdam, Hakan
Sabir, Nuran
Kiraç, S.
Keywords: amino acid
chromogranin
essential fatty acid
heparin
insulin
octreotide
pentetreotide in 111
zinc
adult
article
case report
chemoembolization
computer assisted tomography
deep vein thrombosis
diabetic ketoacidosis
erythema
female
glucagonoma
human
immunohistochemistry
liver metastasis
lung embolism
malignant neoplastic disease
necrolytic migratory erythema
non insulin dependent diabetes mellitus
pancreas resection
scintigraphy
skin manifestation
splenectomy
treatment outcome
Adult
Diabetic Ketoacidosis
Erythema
Female
Glucagonoma
Humans
Liver Neoplasms
Pancreatic Neoplasms
Abstract: A 44-year-old woman was diagnosed with type II diabetes in 1998 and 1 year later she developed necrolytic migratory erythema, which is a specific skin lesion of glucagonoma. During the clinical investigation, a nodular 6cm mass in the distal pancreatic region and multiple cystic liver metastases were found. She was operated on, and glucagonoma was detected and the long-acting, repeatable, octreotide treatment was started. 3 years after resection of a pancreatic glucagonoma she presented to a hospital emergency department with diabetic ketoacidosis. Hepatic multiple cystic metastases were visualized by computed tomography. During hospitalization she developed severe pulmonary embolism and deep-venous thrombosis of the lower extremities. Indium-labeled octeotide scintigraphy showed multiple cystic lesions in the liver with additional lesions in the iliocecal region, which had not been visualized by computed tomography. Despite somatostatin therapy the tumor had expanded in the liver. Arterial chemoembolization was performed but 6 months later she died. © 2005 Society for Endocrinology.
URI: https://hdl.handle.net/11499/4859
https://doi.org/10.1677/erc.1.00957
ISSN: 1351-0088
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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