Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4868
Title: No association of the CAG repeat length in exon 1 of the androgen receptor gene with idiopathic infertility in Turkish men: Implications and literature review
Authors: Tufan, Ahmet Çevik
Şatıroğlu-Tufan, Naciye Lale
Aydınuraz, Batu
Şatıroğlu, M. Hakan
Aydos, Kaan
Bağcı, Hüseyin
Keywords: Androgen receptor gene
CAG repeat
Defective spermatogenesis
Male infertility
adenine
androgen receptor
cytosine
DNA
follitropin
guanine
luteinizing hormone
testosterone
adult
article
azoospermia
Caucasian
cell structure
clinical article
concentration (parameters)
controlled study
correlation analysis
DNA determination
ethnic difference
ethnology
Europe
exon
follitropin blood level
gene frequency
genetic association
genetic variability
human
human cell
idiopathic disease
luteinizing hormone blood level
male
male infertility
North America
oligospermia
population genetics
spermatogenesis
spermatozoon motility
statistical significance
testis function
testosterone blood level
trinucleotide repeat
Turkey (republic)
Adult
Aged
Base Sequence
Exons
Humans
Infertility, Male
Male
Middle Aged
Receptors, Androgen
Repetitive Sequences, Nucleic Acid
Turkey
Abstract: While the correlation between the CAG repeat length of the androgen receptor (AR) gene and idiopathic male infertility is still unclear, ethnic background of the population studied may play an important role in this association. The objective of this study was to determine whether changes in the CAG repeat length are associated with spermatogenic defects in Turkish infertile men. Reproductive hormone concentrations and the CAG repeat length in exon 1 of the AR gene in 47 idiopathic infertile men and 32 fertile controls were analyzed. The mean serum luteinising hormone (LH) and follicle stimulating hormone (FSH) levels were significantly higher in the infertile group than those of the control group (p < 0.0001 for both comparisons), whereas the mean serum testosterone level in the infertile group did not differ significantly from that in the control group (p = 0.16). The mean CAG repeat length of the AR gene in the infertile group did not differ significantly from that in the control group (22.28 ± 0.37 vs 22.41 ± 0.54, respectively; p = 0.84). In addition, the frequency of having a CAG repeat number (? 24) was also comparable between the infertile patients and fertile controls (31.9% vs 40.6%, respectively; p = 0.21). In conclusion, reproductive hormones with elevated LH and FSH, and normal or low testosterone levels were suggestive of partial impairment of testicular function. However, no statistically significant relationship between the length of the CAG repeat and idiopathic impaired sperm production was observed in the Turkish population studied. These results support the findings of previously published European studies, but are contrary to the findings from Caucasian and North American population studies. Thus, ethnicity and genetic backgrounds seem to be important in this association, and studies from a variety of different ethnic and genetic backgrounds using comparable patient subgroups are valuable to further evaluate this association. © 2005 Tohoku University Medical Press.
URI: https://hdl.handle.net/11499/4868
https://doi.org/10.1620/tjem.206.105
ISSN: 0040-8727
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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