Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4871
Title: The effects of hyperbilirubinemia on sleep-spindle characteristics in infants
Authors: Gürses, Dolunay
Kılıç, İmren
Şahiner, Türker
Keywords: Brain maturation
Electroencephalogram
Hyperbilirubinemia
Infant
Sleep spindle
bilirubin
amplitude modulation
article
bilirubin blood level
clinical article
correlation analysis
disease duration
electroencephalogram
frequency analysis
high risk population
human
hyperbilirubinemia
infant
neurophysiology
nonREM sleep
priority journal
sleep pattern
sleep spindle
Publisher: American Academy of Sleep Medicine
Abstract: Objective: The purpose of this study is to investigate the effect of hyperbilirubinemia on sleep-spindle characteristics. Rhythmic activities, such as sleep spindles, may be abolished by hyperbilirubinemia. Study Design: Electroencephalogram records were taken from 15 infants with hyperbilirubinemia and 18 healthy infants at the 12th week after birth. Sleep spindles of the 2 groups were compared according to location, density, duration,amplitude, frequency, asynchrony, and asymmetry. Results: In the study and control groups, the density of the spindles was found to be 76.9 ± 23.7 and 105.2 ± 33.9, respectively, in a 1-hour non-rapid eye movement sleep period. The mean durations of the sleep spindles in the study and control groups were found to be 4105 ± 802 milliseconds and 5162 ± 1075 milliseconds, respectively. There was not any difference between the groups according to the amplitude and asymmetry. However, there was a significant difference between the 2 groups in the frequency of spindles. The mean frequency was found to be 12.5 ± 0.6 Hz in the study group and 13.2 ± 0.9 in the control group. The percentage of asynchronous spindles was higher in the study group than in the control group. There was a significant negative correlation between the bilirubin levels during the newborn period and density, duration, and frequency of spindles. However, there was a significantly positive correlation between the bilirubin levels and percentage of asynchronous spindles. There was a significant negative correlation between the duration of hyperbilirubinemia and spindleamplitude. Conclusion: We suggest that studies on the critical maturation periods of sleep-spindle patterns might provide a sensitive tool for early diagnosis of neurophysiologic brain alterations during the first trimester of life in a population of at-risk children, such as jaundiced infants.
URI: https://hdl.handle.net/11499/4871
https://doi.org/10.1093/sleep/28.5.644
ISSN: 0161-8105
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record



CORE Recommender

SCOPUSTM   
Citations

6
checked on Jun 14, 2024

WEB OF SCIENCETM
Citations

6
checked on Jun 14, 2024

Page view(s)

48
checked on May 27, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.