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https://hdl.handle.net/11499/4873
Title: | Impact of obstructive sleep apnea on right ventricular global function: Sleep apnea and myocardial performance index | Authors: | Dursunoglu, Neşe Dursunoglu, Dursun Kılıç, Mustafa |
Keywords: | Myocardial performance index, right ventricular Obstructive sleep apnea adult arterial oxygen saturation arterial oxygen tension article body mass clinical article controlled study correlation analysis demography diastolic blood pressure disease severity female heart left ventricle ejection fraction heart performance heart rate heart right ventricle failure heart right ventricle function heart ventricle function heart ventricle septum heart ventricle size heart ventricle wall human hypoxic lung vasoconstriction lung volume M mode echocardiography male medical assessment mitral valve polysomnography priority journal sleep apnea syndrome statistical analysis systolic blood pressure tricuspid valve Adult Female Heart Ventricles Humans Male Middle Aged Organ Size Reference Values Sleep Apnea, Obstructive Ventricular Function, Left Ventricular Function, Right |
Abstract: | Background: Obstructive sleep apnea (OSA) is characterized by repetitive upper airway obstructions during sleep, and it might cause cardiovascular complications such as heart failure, arrhythmias, myocardial infarction, systemic and pulmonary hypertension. Objectives: To determine right ventricular diameters and myocardial performance index (MPI) reflecting ventricular global function in uncomplicated OSA patients. Methods: 49 subjects without hypertension, diabetes mellitus, or any cardiac or pulmonary disease referred for evaluation of OSA had overnight polysomnography and complete echocardiographic assessment. According to the apnea-hypopnea index (AHI), subjects were divided into three groups: group 1: control subjects (AHI <5, n = 20), group 2: patients with mild OSA (AHI: 5-14, n = 11), and group 3: moderate-severe OSA (AHI ? 15, n = 18). Right ventricular free wall diameter was measured by M mode, and right ventricular MPI was calculated as (isovolumic contraction time + isovolumic relaxation time)/pulmonary ejection time. Results: There were no differences of age, body mass index, heart rates, systolic and diastolic blood pressures among the groups (p > 0.05). Right ventricular end-diastolic and end-systolic diameters were not statistically different between the groups, and were within normal limits. Also, right ventricular free wall diameter was not significantly different between the groups of control, mild OSA and moderate-severe OSA (6.7 ± 0.9, 6.9 ± 1.0, 7.1 ± 1.1 mm, p > 0.05). Right ventricular diastolic dysfunction was shown only in group 3 patients. Right ventricular MPI was statistically higher in group 3 (0.62 ± 0.18) than in group 2 patients (0.50 ± 0.10), and group 1 patients (0.48 ± 0.08, p < 0.001). Conclusions: It was suggested that patients with moderate-severe OSA had a right ventricular global dysfunction, in addition to the presence of a diastolic dysfunction. Copyright © 2005 S. Karger AG. | URI: | https://hdl.handle.net/11499/4873 https://doi.org/10.1159/000085369 |
ISSN: | 0025-7931 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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