Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4876
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dc.contributor.authorEgashira, N.-
dc.contributor.authorIwasaki, K.-
dc.contributor.authorAkiyoshi, Y.-
dc.contributor.authorTakagaki, Y.-
dc.contributor.authorHatip-Al-Khatib, İzzettin.-
dc.contributor.authorMishima, K.-
dc.contributor.authorKurauchi, K.-
dc.date.accessioned2019-08-16T11:38:19Z
dc.date.available2019-08-16T11:38:19Z
dc.date.issued2005-
dc.identifier.issn0951-418X-
dc.identifier.urihttps://hdl.handle.net/11499/4876-
dc.identifier.urihttps://doi.org/10.1002/ptr.1671-
dc.description.abstractAmyloid ß protein (Aß) is the major component of senile plaques, the pathological hallmark of the neurodegeneration associated with Alzheimer's disease (AD). This study investigated the effect of Toki-shakuyaku-san (TSS), a traditional medicine, on Aß25-35-induced neuronal death and lipid peroxidation assessed by measuring lactate dehydrogenase (LDH) and malondialdehyde (MDA), respectively. Aß25-35 at 10 µM induced neuronal damage and increased the LDH and MDA. TSS at concentrations of 100 and 300 µg/mL significantly reduced the Aß25-35-induced neuronal death and the lipid peroxidation. These results suggest that TSS has a protective effect against Aß25-35-induced neuronal damage. TSS may be beneficial for the treatment of AD. Copyright © 2005 John Wiley & Sons, Ltd.en_US
dc.language.isoenen_US
dc.relation.ispartofPhytotherapy Researchen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectß-amyloiden_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectLactate dehydrogenase (LDH) activityen_US
dc.subjectLipid peroxidationen_US
dc.subjectNeuronal damageen_US
dc.subjectToki-shakuyaku-sanen_US
dc.subjectamyloid beta protein[25-35]en_US
dc.subjectherbaceous agenten_US
dc.subjectlactate dehydrogenaseen_US
dc.subjectmalonaldehydeen_US
dc.subjecttoki shakuyaku sanen_US
dc.subjectunclassified drugen_US
dc.subjectAlzheimer diseaseen_US
dc.subjectanimal cellen_US
dc.subjectarticleen_US
dc.subjectbrain cellen_US
dc.subjectconcentration responseen_US
dc.subjectcontrolled studyen_US
dc.subjectlipid peroxidationen_US
dc.subjectnerve cell cultureen_US
dc.subjectnerve degenerationen_US
dc.subjectnerve injuryen_US
dc.subjectnonhumanen_US
dc.subjectraten_US
dc.subjectsenile plaqueen_US
dc.subjecttraditional medicineen_US
dc.subjectAmyloid beta-Proteinen_US
dc.subjectAnimalsen_US
dc.subjectApoptosisen_US
dc.subjectCerebral Cortexen_US
dc.subjectDose-Response Relationship, Drugen_US
dc.subjectDrugs, Chinese Herbalen_US
dc.subjectL-Lactate Dehydrogenaseen_US
dc.subjectLipid Peroxidationen_US
dc.subjectMalondialdehydeen_US
dc.subjectNeuronsen_US
dc.subjectNeuroprotective Agentsen_US
dc.subjectPeptide Fragmentsen_US
dc.subjectPhytotherapyen_US
dc.subjectRatsen_US
dc.subjectRats, Wistaren_US
dc.titleProtective effect of Toki-shakuyaku-san on amyloid ß25-35- induced neuronal damage in cultured rat cortical neuronsen_US
dc.typeArticleen_US
dc.identifier.volume19en_US
dc.identifier.issue5en_US
dc.identifier.startpage450
dc.identifier.startpage450en_US
dc.identifier.endpage453en_US
dc.authorid0000-0002-9127-6779-
dc.identifier.doi10.1002/ptr.1671-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid16106382en_US
dc.identifier.scopus2-s2.0-24644504769en_US
dc.identifier.wosWOS:000231575700016en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale_University-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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