Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4876
Full metadata record
DC FieldValueLanguage
dc.contributor.authorEgashira, N.-
dc.contributor.authorIwasaki, K.-
dc.contributor.authorAkiyoshi, Y.-
dc.contributor.authorTakagaki, Y.-
dc.contributor.authorHatip-Al-Khatib, İzzettin.-
dc.contributor.authorMishima, K.-
dc.contributor.authorKurauchi, K.-
dc.date.accessioned2019-08-16T11:38:19Z
dc.date.available2019-08-16T11:38:19Z
dc.date.issued2005-
dc.identifier.issn0951-418X-
dc.identifier.urihttps://hdl.handle.net/11499/4876-
dc.identifier.urihttps://doi.org/10.1002/ptr.1671-
dc.description.abstractAmyloid ß protein (Aß) is the major component of senile plaques, the pathological hallmark of the neurodegeneration associated with Alzheimer's disease (AD). This study investigated the effect of Toki-shakuyaku-san (TSS), a traditional medicine, on Aß25-35-induced neuronal death and lipid peroxidation assessed by measuring lactate dehydrogenase (LDH) and malondialdehyde (MDA), respectively. Aß25-35 at 10 µM induced neuronal damage and increased the LDH and MDA. TSS at concentrations of 100 and 300 µg/mL significantly reduced the Aß25-35-induced neuronal death and the lipid peroxidation. These results suggest that TSS has a protective effect against Aß25-35-induced neuronal damage. TSS may be beneficial for the treatment of AD. Copyright © 2005 John Wiley & Sons, Ltd.en_US
dc.language.isoenen_US
dc.relation.ispartofPhytotherapy Researchen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectß-amyloiden_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectLactate dehydrogenase (LDH) activityen_US
dc.subjectLipid peroxidationen_US
dc.subjectNeuronal damageen_US
dc.subjectToki-shakuyaku-sanen_US
dc.subjectamyloid beta protein[25-35]en_US
dc.subjectherbaceous agenten_US
dc.subjectlactate dehydrogenaseen_US
dc.subjectmalonaldehydeen_US
dc.subjecttoki shakuyaku sanen_US
dc.subjectunclassified drugen_US
dc.subjectAlzheimer diseaseen_US
dc.subjectanimal cellen_US
dc.subjectarticleen_US
dc.subjectbrain cellen_US
dc.subjectconcentration responseen_US
dc.subjectcontrolled studyen_US
dc.subjectlipid peroxidationen_US
dc.subjectnerve cell cultureen_US
dc.subjectnerve degenerationen_US
dc.subjectnerve injuryen_US
dc.subjectnonhumanen_US
dc.subjectraten_US
dc.subjectsenile plaqueen_US
dc.subjecttraditional medicineen_US
dc.subjectAmyloid beta-Proteinen_US
dc.subjectAnimalsen_US
dc.subjectApoptosisen_US
dc.subjectCerebral Cortexen_US
dc.subjectDose-Response Relationship, Drugen_US
dc.subjectDrugs, Chinese Herbalen_US
dc.subjectL-Lactate Dehydrogenaseen_US
dc.subjectLipid Peroxidationen_US
dc.subjectMalondialdehydeen_US
dc.subjectNeuronsen_US
dc.subjectNeuroprotective Agentsen_US
dc.subjectPeptide Fragmentsen_US
dc.subjectPhytotherapyen_US
dc.subjectRatsen_US
dc.subjectRats, Wistaren_US
dc.titleProtective effect of Toki-shakuyaku-san on amyloid ß25-35- induced neuronal damage in cultured rat cortical neuronsen_US
dc.typeArticleen_US
dc.identifier.volume19en_US
dc.identifier.issue5en_US
dc.identifier.startpage450
dc.identifier.startpage450en_US
dc.identifier.endpage453en_US
dc.authorid0000-0002-9127-6779-
dc.identifier.doi10.1002/ptr.1671-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid16106382en_US
dc.identifier.scopus2-s2.0-24644504769en_US
dc.identifier.wosWOS:000231575700016en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale_University-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeArticle-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Show simple item record



CORE Recommender

SCOPUSTM   
Citations

35
checked on Nov 16, 2024

WEB OF SCIENCETM
Citations

32
checked on Nov 21, 2024

Page view(s)

42
checked on Aug 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.