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https://hdl.handle.net/11499/4884
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Çobankara, Veli | - |
dc.contributor.author | Öztürk, M.A. | - |
dc.contributor.author | Kiraz, S. | - |
dc.contributor.author | Ertenli, I. | - |
dc.contributor.author | Haznedaroglu, I.C. | - |
dc.contributor.author | Pay, S. | - |
dc.contributor.author | Çalgüneri, M. | - |
dc.date.accessioned | 2019-08-16T11:38:25Z | |
dc.date.available | 2019-08-16T11:38:25Z | |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0172-8172 | - |
dc.identifier.uri | https://hdl.handle.net/11499/4884 | - |
dc.identifier.uri | https://doi.org/10.1007/s00296-004-0564-8 | - |
dc.description.abstract | Local functional renin-angiotensin systems (RAS) have been demonstrated in many organ and tissue systems. Angiotensins, the effector growth factors of the RAS, are essentially cytokines and growth factors which actively contribute to many inflammatory reactions. Among the components of RAS, angiotensin-converting enzyme (ACE) and renin have been previously investigated separately in RA. In this study, ACE levels and renin concentrations were measured in the sera of 16 patients with RA (median age: 45 (26-69), male/female: 3/13), 13 patients with osteoarthritis (OA) (median age: 55 (28-72), male/female: 5/8), and 11 healthy adults (median age: 44 (35-70), male/female: 6/5). Synovial ACE levels and renin concentrations were also measured concurrently in patients with RA and OA. Serum ACE levels were comparable between the groups. However, synovial fluid ACE levels were significantly higher in the patients with RA than in patients with OA. Likewise, synovial fluid renin concentrations were higher in RA patients than in OA patients, while serum renin concentrations were similar in patients with RA and OA and in healthy controls. Moreover, there was a significant negative correlation between the duration of the disease and synovial renin concentrations in RA patients. In conclusion, locally-generated active renin and ACE could contribute to joint destruction in rheumatoid arthritis. © Springer-Verlag 2005. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Rheumatology International | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Angiotensin-converting enzyme | en_US |
dc.subject | Local synovial renin-angiotensin system | en_US |
dc.subject | Renin | en_US |
dc.subject | Rheumatoid arthritis | en_US |
dc.subject | cytokine | en_US |
dc.subject | dipeptidyl carboxypeptidase | en_US |
dc.subject | renin | en_US |
dc.subject | adult | en_US |
dc.subject | age distribution | en_US |
dc.subject | aged | en_US |
dc.subject | article | en_US |
dc.subject | clinical article | en_US |
dc.subject | controlled study | en_US |
dc.subject | correlation analysis | en_US |
dc.subject | female | en_US |
dc.subject | human | en_US |
dc.subject | male | en_US |
dc.subject | osteoarthritis | en_US |
dc.subject | priority journal | en_US |
dc.subject | renin angiotensin aldosterone system | en_US |
dc.subject | rheumatoid arthritis | en_US |
dc.subject | sex ratio | en_US |
dc.subject | synovial fluid | en_US |
dc.subject | Adult | en_US |
dc.subject | Aged | en_US |
dc.subject | Arthritis, Rheumatoid | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Male | en_US |
dc.subject | Middle Aged | en_US |
dc.subject | Osteoarthritis | en_US |
dc.subject | Peptidyl-Dipeptidase A | en_US |
dc.subject | Renin-Angiotensin System | en_US |
dc.subject | Synovial Fluid | en_US |
dc.title | Renin and angiotensin-converting enzyme (ACE) as active components of the local synovial renin-angiotensin system in rheumatoid arthritis | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 25 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 285 | |
dc.identifier.startpage | 285 | en_US |
dc.identifier.endpage | 291 | en_US |
dc.identifier.doi | 10.1007/s00296-004-0564-8 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 15761728 | en_US |
dc.identifier.scopus | 2-s2.0-20044372578 | en_US |
dc.identifier.wos | WOS:000229070200010 | en_US |
dc.identifier.scopusquality | Q2 | - |
dc.owner | Pamukkale_University | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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