Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4913
Title: Angiotensin-converting enzyme polymorphism in Turkish male athletes: Relationship to left ventricular mass and function
Authors: Dursunoğlu, Dursun
Tanrıverdi, Halil
Evrengul, H.
Turgut, G.
Turgut, S.
Genç, O.
Kaftan, H.A.
Keywords: ACE polymorphism
Athletes
Left ventricular function
Left ventricular mass
angiotensin
dipeptidyl carboxypeptidase
adult
age
article
athlete
blood analysis
body mass
calculation
controlled study
diastolic blood pressure
echocardiography
enzyme activity
enzyme blood level
enzyme polymorphism
gene deletion
gene frequency
gene insertion
genetic marker
genotype
heart left ventricle
heart left ventricle ejection fraction
heart left ventricle function
heart left ventricle hypertrophy
heart left ventricle mass
heart left ventricle wall
heart muscle
heart rate
heart ventricle septum
human
human experiment
male
molecular cloning
polymerase chain reaction
risk assessment
sport
statistical significance
systolic blood pressure
Abstract: Angiotensin-converting enzyme (ACE) is a key enzyme in the production of angiotensin II. The cloning of the ACE gene has made it possible to identify a deletion (D)-insertion (I) polymorphism that appears to affect the level of serum ACE activity. The aim of our study was to analyse the ACE gene I/D polymorphism in Turkish male athletes and to evaluate its relationship to left ventricular mass and function. Forty male athletes (mean age 23.4±1.8 years) were included in this study, and they underwent both complete echocardiographic assessment and analysis of ACE I and D aliele frequencies in peripheral blood by polymerase chain reaction. They were separated into three subgroups according to their ACE DD (n=13), DI (n=16) and II (n=11) genotypes. Thickness of the interventricular septum (IVS), the left ventricular posterior wall (LVPW) and left ventricular mass (LVM) and LVM index (LVMI) were measured by the M-mode. Left ventricular ejection fraction was calculated using Simpson's method, and so was the myocardial performance index. There was no statistically significant differences between the ACE DD, DI and II genotypes at the p>0.05 level by age, body mass index, heart rate, systolic and diastolic blood pressures. The thickness of the IVS (12 mm) and LVPW (10.7 mm), and LVM (302.8 g) and LVMI (157.3 g/m2) in ACE DD genotypes were higher than for both ACE DI (10.8 mm; 9.7 mm; 231.9 g; 125.3 g/m2) and II genotypes (9.0 mm; 8.6 mm; 185.0 g; 107.5 g/m2) in athletes. Left ventricular systolic and global functions among the three ACE genotypes were not different statistically. Our findings suggest that left ventricular hypertrophy is partially determined by genetic disposition and DD genotype of ACE is a potential genetic marker associated with an elevated risk of left ventricular hypertrophy.
URI: https://hdl.handle.net/11499/4913
ISSN: 0969-6113
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

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