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https://hdl.handle.net/11499/4917
Title: | Acute effects of automated continuous positive airway pressure on blood pressure in patients with sleep apnea and hypertension | Authors: | Dursunoglu, Neşe Dursunoglu, Dursun Çuhadaroglu, Ç. Kiliçaslan, Z. |
Keywords: | Automated continuous positive airway pressure therapy Blood pressure monitoring Heart rate Hypertension Sleep apnea adult article automation blood pressure blood pressure monitoring clinical article clinical trial controlled clinical trial controlled study diastolic blood pressure disease severity heart beat heart rate hemodynamic parameters human hypertension night polysomnography positive end expiratory pressure priority journal sleep apnea syndrome systolic blood pressure Blood Pressure Blood Pressure Monitoring, Ambulatory Circadian Rhythm Continuous Positive Airway Pressure Follow-Up Studies Heart Rate Humans Middle Aged Polysomnography Sleep Apnea Syndromes Treatment Outcome |
Abstract: | Background: The obstructive sleep apnea-hypopnea syndrome (OSAHS) is characterized by repetitive upper airway obstructions during sleep, and it might cause cardiovascular complications such as myocardial infarction, arrhythmias, and systemic and pulmonary hypertension. Objectives: We investigated the acute effects of automatic continuous positive airway pressure (automated CPAP) on blood pressure in patients with OSAHS and hypertension. Methods: Polysomnography was used and ambulatory blood pressure measurements were done in 12 patients with OSAHS. Blood pressure and heart rate were measured at night (10 p.m. to 6 a.m.) and during the day (6 a.m. to 10 p.m.). During these periods systolic, diastolic and mean blood pressure and heart rate of the patients on the diagnostic day were compared with those on the treatment day. Results: Patients had moderate or severe OSAHS; their mean age was 52.8 ± 4.2 years. Systolic, diastolic and mean blood pressure and heart rate between the diagnostic and treatment day were not significantly different. Standard deviations of all these parameters during the night of the treatment day (9.1 ± 4.5, 7.5 ± 3.3, 8.0 ± 3.0 mm Hg, and 4.8 ± 1.5 beats/min, respectively) were significantly lower than during the night of the diagnostic day (12.6 ± 4.9 mm Hg, p = 0.023, 10.8 ± 3.5 mm Hg, p = 0.004, 11.6 ± 4.4 mm Hg, p = 0.006 and 6.9 ± 1.6 beats/min, p = 0.003, respectively). We did not find similar results during daytime periods. Conclusions: Automated CPAP therapy in patients with sleep apnea and hypertension did not decrease systolic and diastolic blood pressures and heart rates acutely. However, it might reduce the variability of these parameters during sleep in patients, but not during the day. It might be suggested that automated CPAP reduces cardiovascular morbidity of OSAHS via stabilizing heart rate and blood pressure during sleep. Copyright © 2005 S. Karger AG. | URI: | https://hdl.handle.net/11499/4917 https://doi.org/10.1159/000084045 |
ISSN: | 0025-7931 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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