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https://hdl.handle.net/11499/4945
Title: | Obstructive sleep apnea syndrome, endothelial dysfunction and coronary atherosclerosis | Authors: | Dursunoğlu, Neşe Dursunoğlu, Dursun |
Keywords: | adrenergic system anoxia coronary artery atherosclerosis hospitalization human hypertension oxidative stress pathophysiology review risk factor sleep apnea syndrome vascular endothelium Anoxia Coronary Arteriosclerosis Endothelium, Vascular Humans Hypertension Oxidative Stress Risk Factors Severity of Illness Index Sleep Apnea, Obstructive Sympathetic Nervous System |
Abstract: | In obstructive sleep apnea syndrome (OSAS), repetitive episodes of apnea cause increased sympathetic nerve activity, increased surges in arterial blood pressure, swings in intrathoracic pressure, oxidative stres, hypoxia and hypercapnia. The association of OSAS with some diseases, having endothelial dysfunction in their physiopathology, such as hypertension, diabetes mellitus, obesity, coronary artery diseases, stroke and heart failure is common. Increased sympathetic nerve activity and also endothelial dysfunction which are the results of hypoxia, have important roles in vascular complications of OSAS. When compared with healthy population, an important endothelial dysfunction in OSAS patients and relationship between OSAS severity and endothelial dysfunction have been shown. In this review, the relationship between OSAS and endothelial dysfunction was overviewed. | URI: | https://hdl.handle.net/11499/4945 | ISSN: | 0494-1373 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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