Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4969
Title: Investigation of antioxidant effect of zinc biochemically and histopathologically in rats
Authors: Özaslan, M.
Kılıç, I.H.
Aytekin, T.
Güldür, M.E.
Bozkurt, Ali İhsan.
Keywords: alanine aminotransferase
aspartate aminotransferase
carbon tetrachloride
zinc
zinc sulfate
animal experiment
animal model
animal tissue
antioxidant activity
article
cell regeneration
controlled study
histopathology
liver cirrhosis
liver fibrosis
male
nonhuman
rank sum test
rat
staining
statistical significance
Student t test
Animalia
Abstract: In this study, biochemically (Total anti oxidant capacity (TAC), Alanin aminotransferaz (ALT) ve Aspartat aminotransferaz (AST)) and histopathologically effects investigated in CCl4 - treated rats and the effects of intraperitoneal zinc administration on these parameters. Cirrhosis was induced in 40 rats by intraperitoneal injections of CCl4 twice a week over 6 weeks. Forty and ten additional animals were used as controls. Both groups were further subdivided to receive standard diet. TAC, ALT and AST were also worked out. Masson's trichrome stain was applied to evaluate the fibrosis in liver. The results were evaluated by means of Student-t and Mann Whitney U tests in SPSS 6.0. TAC in plasma was significantly different into experimental goups (P <0.05). Value of TAC was lower in B group than in C and D groups (P <0.05), however differences between control and A, C, D groups was not important (P> 0.05). It is found out that the TAC in the groups which treated with CCl4 + ZnSO4 were higher than the groups those treated with only CCl4. This finding support that zinc plays an important role in regeneration of the damaged cells and antioxidant defense mechanism. Moreover, the histopatologic findings of our study were revealed this hypothesis. © 2005 Taylor and Francis Group, LLC.
URI: https://hdl.handle.net/11499/4969
https://doi.org/10.1080/13102818.2005.10817205
ISSN: 1310-2818
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

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