Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5025
Title: Light and scanning electron microscopic examination of late changes in hair with hereditary trichodysplasia (Marie Unna hypotrichosis)
Authors: Celik, H.H.
Surucu, S.H.
Aldur, M.M.
Özdemir, Mehmet Bülent
Karaduman, A.A.
Cumhur, M.M.
Keywords: article
biopsy technique
case report
clinical examination
cuticle
female
hair analysis
hair disease
human
hypotrichosis
image analysis
medical literature
microscopy
preschool child
scanning electron microscopy
skin disease
three dimensional imaging
Turkey (republic)
ultrastructure
university hospital
Biopsy
Child, Preschool
Chromosome Aberrations
Female
Genes, Dominant
Hair
Humans
Hypotrichosis
Microscopy
Microscopy, Electron, Scanning
Surface Properties
Abstract: Objective: Our aim was to investigate the microscopic surface structural alteration in hair with hereditary trichodysplasia. This article presents the results of light and scanning electron microscopy (SEM) examination of cases having hereditary trichodysplasia. Methods: The biopsy specimens were obtained from 2 girls of ages 3 and 5-years, Department of Pediatrics, Faculty of Medicine, Hacettepe University in 2001. A large number of hair specimens were obtained from these 2 cases having hereditary trichodysplasia. Routine light microscopic and SEM procedure was performed on the tissue specimen, and then they were examined by light microscopy and SEM. Results: Hair specimens taken from both patients had great similarities. Our results reveal that the atypical looking hair were flattened, twisted and partly scattered at the end. Moreover, these hairs had sheath structures with abnormal proliferation and these structures were damaged, the cuticles had fractures and were degenerative. Conclusion: There is only a small number of SEM studies in literature reporting the ultrastructural changes of hereditary trichodysplasia. Scanning electron microscopy is a 3 dimensional examination technique revealing easily comparable images and it is indispensable for diagnosis in various tissues which permit considerable magnification. As it is used in the hereditary trichodysplasia syndrome its routine usage in many dermatologic and hair diseases will result in valuable contributions to scientific literature.
URI: https://hdl.handle.net/11499/5025
ISSN: 0379-5284
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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