Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/50379
Title: Associations of IL-17 and IL-17 receptor polymorphisms with Behcet's disease in Denizli Provİnce of Turkey
Authors: Arıkan, Sanem
Öztürk, Onur
Duygulu, Şeniz
Atalay, Erol Ömer
Atalay, Ayfer
Keywords: Behcet's disease
IL-17
IL-17R
Haplotype
SNP
Interleukin-17 Gene Polymorphism
Single-Nucleotide Polymorphisms
Rheumatoid-Arthritis
Susceptibility
Il17a
Pathogenesis
Population
Asthma
17a
Publisher: Humana Press Inc
Abstract: Although the etiopathogenesis of Behcet's disease is not known, studies conducted in different populations show that it is a multifactorial disease that is thought to develop as a result of the interaction of environmental and genetic factors. IL-17 is thought to induce the neutrophilic inflammation and the tissue damage mediated by immune response in patients. Polymorphisms in the gene region encoding IL-17 and IL-17R molecules may play a critical role in the pathogenesis of the disease and contribute to the elucidation of disease mechanism. We aimed to show the association of IL-17A, IL-17F, and IL-17RC polymorphisms and haplotypes in Behcet's disease patients and its clinical features. We genotyped IL-17A (rs4711998 (A/G), rs8193036 (C/T), rs2275913 (A/G), rs3819025 (A/G), rs8193038 (A/G), rs3804513 (A/T), rs1974226 (C/T), rs3748067 (C/T)); IL-17F (rs763780 (T/C), rs2397084 (T/C)); and IL-17R (IL-17RC) (rs708567 (C/T)) polymorphisms in 88 patients with Behcet's disease and 133 healthy controls using PCR-RFLP-based approach. The results of our study showed that polymorphisms of IL-17A, rs8193036 (C/T), rs3819025 (G/A), rs3804513 (A/T), IL-17F rs2397084 (T/C), and IL-17RC rs708567 (C/T) are associated with the susceptibility to the BD. When the haplotype distributions of all loci of IL-17Aand IL-17A/IL-17F together were examined and in contrast to the data obtained from the controls, the GTGGAACC (27.84%) and GTGGAACCTT (25.57%) have the highest frequencies. In conclusion, the allele and genotype frequency differences of the IL-17A, IL-17F, and IL-17R and haplotype frequencies between Behcet's disease and controls indicate that the genetic structure of Behcet's disease may be different.
URI: https://doi.org/10.1007/s12026-023-09363-7
https://hdl.handle.net/11499/50379
ISSN: 0257-277X
1559-0755
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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