Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/50402
Title: | Nerolidol attenuates dehydroepiandrosterone-induced polycystic ovary syndrome in rats by reGülating oxidative stress and decreasing apoptosis | Authors: | Türkmen, Neşe Başak Yüce, Hande Aydın, Muhterem Taşlıdere, Aslı Doğan, Ayşegül Özek, Dilan Askın Hayal, Taha Bartu Yasar, Seyma Ciftci, Osman Unuvar, Songul |
Keywords: | Nerolidol Polycystic ovary syndrome Oxidative stress Apoptosis Dehydroepiandrosterone Syndrome Pcos System Assay |
Publisher: | Pergamon-Elsevier Science Ltd | Abstract: | Aims: Although nerolidol (NRL) is a naturally occurring sesquiterpene alcohol with many pharmacological ac-tivities, its role in dehydroepiandrosterone DHEA-induced polycystic ovary syndrome PCOS is unknown. This study aims to explore the potential beneficial effects and underlying molecular mechanisms of nerolidol treat-ment on polycystic ovary syndrome.Main methods: Pre-pubertal female Sprague-Dawley rats were randomly assigned into four groups (n = 8/group); group I: control; group II: PCOS; group III: P + NRL; group IV: NRL. Biochemical parameters related to oxidative stress, inflammation, apoptosis, and hormones were estimated in the blood and ovarian tissues. Histopatho-logical, ultrastructural, and immunohistochemical analyses were performed. Bax, P53, Cas-3, and Bcl-2 gene expression levels were detected with RT-PCR. The membrane array analysis detected chemokine, cytokine, and growth factor protein profiles.Key findings: In light of the available data, it can deduce that nerolidol has a significant ameliorating effect on lipid peroxidation, oxidative stress, inflammation, histopathological damage, and apoptosis accompanying PCOS in female rats.Significance: PCOS is not only a reproductive pathology but also a systemic condition and its etiopathogenesis is still not fully understood. Sİnce changes in PCOS have important long-term effects on health, this study evaluated the efficacy of nerolidol, a phytotherapeutic for the control of biochemical, apoptotic, histopathological, and metabolic changes. | URI: | https://doi.org/10.1016/j.lfs.2023.121380 https://hdl.handle.net/11499/50402 |
ISSN: | 0024-3205 1879-0631 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Show full item record
CORE Recommender
SCOPUSTM
Citations
1
checked on Oct 13, 2024
WEB OF SCIENCETM
Citations
1
checked on Oct 31, 2024
Page view(s)
42
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.