Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/50402
Title: Nerolidol attenuates dehydroepiandrosterone-induced polycystic ovary syndrome in rats by reGülating oxidative stress and decreasing apoptosis
Authors: Türkmen, Neşe Başak
Yüce, Hande
Aydın, Muhterem
Taşlıdere, Aslı
Doğan, Ayşegül
Özek, Dilan Askın
Hayal, Taha Bartu
Yasar, Seyma
Ciftci, Osman
Unuvar, Songul
Keywords: Nerolidol
Polycystic ovary syndrome
Oxidative stress
Apoptosis
Dehydroepiandrosterone
Syndrome Pcos
System
Assay
Publisher: Pergamon-Elsevier Science Ltd
Abstract: Aims: Although nerolidol (NRL) is a naturally occurring sesquiterpene alcohol with many pharmacological ac-tivities, its role in dehydroepiandrosterone DHEA-induced polycystic ovary syndrome PCOS is unknown. This study aims to explore the potential beneficial effects and underlying molecular mechanisms of nerolidol treat-ment on polycystic ovary syndrome.Main methods: Pre-pubertal female Sprague-Dawley rats were randomly assigned into four groups (n = 8/group); group I: control; group II: PCOS; group III: P + NRL; group IV: NRL. Biochemical parameters related to oxidative stress, inflammation, apoptosis, and hormones were estimated in the blood and ovarian tissues. Histopatho-logical, ultrastructural, and immunohistochemical analyses were performed. Bax, P53, Cas-3, and Bcl-2 gene expression levels were detected with RT-PCR. The membrane array analysis detected chemokine, cytokine, and growth factor protein profiles.Key findings: In light of the available data, it can deduce that nerolidol has a significant ameliorating effect on lipid peroxidation, oxidative stress, inflammation, histopathological damage, and apoptosis accompanying PCOS in female rats.Significance: PCOS is not only a reproductive pathology but also a systemic condition and its etiopathogenesis is still not fully understood. Sİnce changes in PCOS have important long-term effects on health, this study evaluated the efficacy of nerolidol, a phytotherapeutic for the control of biochemical, apoptotic, histopathological, and metabolic changes.
URI: https://doi.org/10.1016/j.lfs.2023.121380
https://hdl.handle.net/11499/50402
ISSN: 0024-3205
1879-0631
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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