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https://hdl.handle.net/11499/50413
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DC Field | Value | Language |
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dc.contributor.author | Aydoğan Kırmızı, Demet | - |
dc.contributor.author | Başer, Emre | - |
dc.contributor.author | Kaymak, Emin | - |
dc.contributor.author | Kılıç, Derya | - |
dc.contributor.author | Onat, Taylan | - |
dc.contributor.author | Özkut, Mahmud Mustafa | - |
dc.date.accessioned | 2023-04-08T09:58:30Z | - |
dc.date.available | 2023-04-08T09:58:30Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 2578-5125 | - |
dc.identifier.issn | 2378-8763 | - |
dc.identifier.uri | https://doi.org/10.1089/can.2022.0242 | - |
dc.identifier.uri | https://hdl.handle.net/11499/50413 | - |
dc.description | Article; Early Access | en_US |
dc.description.abstract | Objective: The preŞent study aimed to demonstrate the possible effects of increased 2-arachidonoylglycerol (2-AG) by applying the monoacylglycerol lipase inhibitor KML-29 on rats with ovarian ischemia-reperfusion (IR) model.Methods: Forty-eight female Wistar albino rats were divided into six groups. Group 1: Sham, Group 2: Ischemia, Group 3: IR, Group 4: IR + KML-29 (2 mg/kg), Group 5: IR + KML-29 (20 mg/kg), and Group 6: IR + vehicle (dimethyl sulfoxide). Three hours of ischemia followed by 3 h of reperfusion. Two different doses of KML-29 (2 and 10 mg/kg) were administered intraperitoneally in Groups 4 and 5, 30 min before reperfusion. Ovarian IR injury and ovarian reserve were evaluated histopathological and by using nuclear factor (NF)-kappa B, interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta 1, superoxide dismuTaşe, glutathione peroxidase pre-/postoperative blood antimullerian hormone, and inhibin B.Results: In the KML-1 and KML-2 groups, this damage was significantly reduced compared to the ischemia group. NF-kappa B, IL-1 beta, TNF-alpha, and TGF-beta 1 immunoreactivities increased statistically significantly in the ischemia group compared to the control group (p<0.001). Immunoreactivities of these proteins were significantly decreased in the KML-1 and KML-2 groups (p<0.001). It was observed that the number of these apoptotic cells decreased significantly in the KML-1 and KML-2 groups compared to the ischemia group (p<0.001). The postoperative inhibin level showed a significant decrease in the ischemia group compared to the sham group, while a significant increase was observed in the KML-1 and KML-2 groups compared to the ischemia group.Conclusion: It was seen that anti-inflammatory, antioxidant, and antiapoptotic activity was formed, and the ovarian reserve was preserved with 2-AG in ovarian IR damage. The protective effect of endocannabinoids on the ovaries may create a promising new treatment strategy for many pathologies that will affect the ovarian reserve. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Mary Ann Liebert, Inc | en_US |
dc.relation.ispartof | Cannabis and Cannabinoid Research | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | 2-AG | en_US |
dc.subject | AMH | en_US |
dc.subject | endocannabinoid | en_US |
dc.subject | KML-19 | en_US |
dc.subject | ovarian ischemia | en_US |
dc.subject | reperfusion | en_US |
dc.subject | ovarian reserve | en_US |
dc.subject | Torsion | en_US |
dc.subject | Detorsion | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Growth | en_US |
dc.title | 2-Arachidonoylglycerol Activity in Over Ischemia Reperfusion Damage: Can Endocannabinoids Protect Ovarian Reserve? | en_US |
dc.type | Article | en_US |
dc.department | Pamukkale University | en_US |
dc.identifier.doi | 10.1089/can.2022.0242 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 36749133 | en_US |
dc.identifier.scopus | 2-s2.0-85190653246 | en_US |
dc.identifier.wos | WOS:000928360200001 | en_US |
dc.institutionauthor | … | - |
dc.identifier.scopusquality | Q1 | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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