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https://hdl.handle.net/11499/50503
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DC Field | Value | Language |
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dc.contributor.author | Tekin, Selma | - |
dc.contributor.author | Bir, Levent Sinan | - |
dc.contributor.author | Avcı, Esin | - |
dc.contributor.author | Şenol, Hande | - |
dc.contributor.author | Tekin, Işık | - |
dc.contributor.author | Cinkir, Ufuk | - |
dc.date.accessioned | 2023-04-08T10:01:56Z | - |
dc.date.available | 2023-04-08T10:01:56Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 2168-8184 | - |
dc.identifier.uri | https://doi.org/10.7759/cureus.26981 | - |
dc.identifier.uri | https://hdl.handle.net/11499/50503 | - |
dc.description.abstract | Background Multiple sclerosis (MS) is a major global problem, and as its pathogenesis is understood more clearly, therapeutic options expand accordingly. The mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is a novel mitochondria-derived protein acting on metabolic homeosTaşis. In this study, we aimed to investigate the role of serum MOTS-c in the pathophysiology of the disease in MS patients and to discuss the mechanism of MOTS-c. Methodology In total, 43 patients diagnosed with relapsing-remitting MS and 41 healthy controls were enrolled in the study. MOTS-c, fasting blood glucose, insulin, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), lipid panel, and body mass index levels were assessed. Results The participants' MOTS-c levels remained significantly lower than that of the control group, while their fasting blood glucose and HOMA-IR values were higher. The multivariate logistic regression analysis established that increased MOTS-c levels could be a protective factor against the development of MS disease. The area under the receiver operating characteristic curve for MOTS-c was calculated as 0.782 (95% confidence interval = 0.684-0.879, p = 0.0001). Conclusions This study is the first to scrutinize MOTS-c levels in MS patients. We tried to provide clinical evidence that MOTS-c could act as a highly discriminative biomarker between MS patients and control groups, which may hold great promise for future therapeutic options. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Cureus Inc | en_US |
dc.relation.ispartof | Cureus Journal of Medical Science | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | hypertension | en_US |
dc.subject | hyperlipidemia | en_US |
dc.subject | diabetes mellitus | en_US |
dc.subject | homa-ir | en_US |
dc.subject | ms patients | en_US |
dc.subject | mots-c | en_US |
dc.subject | multiple sclerosis | en_US |
dc.subject | Insulin-Resistance | en_US |
dc.title | Comparison of Serum Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) Levels in Patients With Multiple Sclerosis and Healthy Controls | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | 7 | en_US |
dc.department | Pamukkale University | en_US |
dc.identifier.doi | 10.7759/cureus.26981 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 35989823 | en_US |
dc.identifier.wos | WOS:000835494500006 | en_US |
dc.institutionauthor | … | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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File | Size | Format | |
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Comparison of Serum Mitochondrial.pdf | 221.35 kB | Adobe PDF | View/Open |
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