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https://hdl.handle.net/11499/50504
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DC Field | Value | Language |
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dc.contributor.author | Karslı, Emre | - |
dc.contributor.author | Anabarlı Metin, Damla | - |
dc.contributor.author | Canacık, Ömer | - |
dc.contributor.author | Sabırlı, Ramazan | - |
dc.contributor.author | Kaymaz, Buse | - |
dc.contributor.author | Kurt, Özgür | - |
dc.contributor.author | Köseler, Aylin | - |
dc.date.accessioned | 2023-04-08T10:01:56Z | - |
dc.date.available | 2023-04-08T10:01:56Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 2168-8184 | - |
dc.identifier.uri | https://doi.org/10.7759/cureus.28805 | - |
dc.identifier.uri | https://hdl.handle.net/11499/50504 | - |
dc.description.abstract | Background Recent studies have investigated the importance of Galetin-3 in inflammation, fibrosis, cell proliferation, cardiac disease, diabetes, and tumor formation. Aims This study aims to investigate the role of the Galectin-3 level in the diagnosis of COVID-19 pneumonia and the value of the Galectin-3 level in predicting the clinical course of the patient. Methods This study employed a prospective, case-control study design and was conducted at Bakircay University Cigli Training and Research Hospital. A total of 100 patients (40 had moderate and 60 had severe/critical COVID-19 disease according to World Health Organisation guidelines) and 50 non-symptomatic healthy volunteers participated in the study. Blood samples were taken from patients at the time of hospital admission, after which serum was isolated. Following the isolation of serum, Galectin-3 levels were evaluated using the enzyme-linked immunosorbent assay (ELISA) method. Results The serum Galectin-3 level was measured as 13.57 (10.9-16.4) ng/mL in the control group, 13.52 (10.69-16.6) ng/mL in the moderate disease group, and 11.65 (6.09-14.33) ng/mL in the severe/critical disease group. Serum Galectin-3 levels were significantly lower in the severe/critical disease group compared to the control and moderate disease groups (p=0.001 and p=0.019, respectively). Using ROC analysis, a larger area under the curve (AUC) for the serum Galectin-3 levels of the control group (AUC-0.622, 95% CI =0.529-0.714; p=0.015) was calculated compared to the COVID-19 patient group for the diagnosis of COVID-19 disease. The Galectin-3 level was found to be 75% Şensitive and 50% specific at a cut-off level of 11.3 ng/mL in predicting the need for ICU treatment. Conclusion Galectin-3 levels may be a beneficial biomarker in predicting the clinical severity of COVID-19 disease when used in conjunction with other known biomarkers, at the time of admission to the emergency department (ED). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Cureus Inc | en_US |
dc.relation.ispartof | Cureus Journal of Medical Science | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | inflamation | en_US |
dc.subject | clinical infectious disease | en_US |
dc.subject | covid-19 pneumonia | en_US |
dc.subject | covid-19 | en_US |
dc.subject | galectin-3 | en_US |
dc.subject | Galectin-3 | en_US |
dc.subject | Severity | en_US |
dc.subject | Neutrophil | en_US |
dc.subject | Pneumonia | en_US |
dc.title | Gaiectin-3 as a Potential Prognostic Biomarker for COVID-19 Disease: A Case-Control Study | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | 9 | en_US |
dc.department | Pamukkale University | en_US |
dc.authorid | Köseler, Aylin/0000-0003-4832-0436 | - |
dc.identifier.doi | 10.7759/cureus.28805 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorwosid | Köseler, Aylin/C-5030-2012 | - |
dc.identifier.pmid | 36225452 | en_US |
dc.identifier.wos | WOS:000888596900022 | en_US |
dc.institutionauthor | … | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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File | Size | Format | |
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cureus-0014-00000028805.pdf | 483.91 kB | Adobe PDF | View/Open |
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