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https://hdl.handle.net/11499/5084
Title: | Is procalcitonin a reliable marker for the diagnosis of infected pancreatic necrosis? | Authors: | Yonetci, N. Sungurtekin, Uğur Oruç, Nevin Yiımaz, Mustafa Sungurtekin, Hülya Kaleli, İlknur Kaptanoglu, B. |
Keywords: | Cerulein Pancreatic necrosis Pancreatitis Procalcitonin Taurocholate acute phase protein amylase biochemical marker C reactive protein ceruletide interleukin 6 interleukin 8 procalcitonin taurocholic acid tumor necrosis factor alpha acute disease animal experiment animal model animal tissue article controlled study correlation analysis disease marker disease severity edema evaluation female histology hormone blood level infection nonhuman pancreas necrosis pancreatitis protein blood level rat Animals Biological Markers Calcitonin Female Necrosis Pancreas Pancreatic Diseases Protein Precursors Rats Rats, Wistar Reproducibility of Results |
Abstract: | Background: Infected necrosis in acute pancreatitis is the main factor in determining the prognosis of the disease. Early and accurate diagnosis of infected pancreatic necrosis might decrease mortality. The aim of the present study is to identify a reliable marker for the onset infection in three different experimentally induced pancreatitis models. Methods: Ninety female Wistar albino rats were randomly divided into nine groups. In three different experimental models, including cerulein induced acute oedematous pancreatitis (AEP), sterile pancreatic necrosis due to taurocholate-induced acute pancreatitis (SPN) and infected pancreatic necrosis taurocholate-induced acute pancreatitis (IPN). Serum levels of procalcitonin (PCT), C-reactive protein (CRP), tumour necrosis factor a (TNF-?), interleukin 6 (IL-6) and interleukin 8 (IL-8), amylase were measured. The degree of pancreatic damage also evaluated pathologically. Results: Procalcitonin levels were increased significantly in AEP, SPN and IPN compared to control groups (P < 0.05). PCT and IL-6 level were the highest in the IPN group (P < 0.05). Serum amylase, CRP, TNF-?, IL-2, and IL-8 levels were similar between IPN and SPN groups (P > 0.05), but higher than in other groups. The results of histological evaluation also correlated with the advent of the disease. Conclusion: Procalcitonin and IL-6 acts as reliable acute phase reactant in an experimental model of AEP, SPN and IPN in the rat. PCT and IL-6 combination might be surrogate marker of infected pancreatic necrosis and should be preferred to other markers assay especially in severe pancreatitis. | URI: | https://hdl.handle.net/11499/5084 https://doi.org/10.1111/j.1445-2197.2004.03059.x |
ISSN: | 1445-1433 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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