Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5084
Title: Is procalcitonin a reliable marker for the diagnosis of infected pancreatic necrosis?
Authors: Yonetci, N.
Sungurtekin, Uğur
Oruç, Nevin
Yiımaz, Mustafa
Sungurtekin, Hülya
Kaleli, İlknur
Kaptanoglu, B.
Keywords: Cerulein
Pancreatic necrosis
Pancreatitis
Procalcitonin
Taurocholate
acute phase protein
amylase
biochemical marker
C reactive protein
ceruletide
interleukin 6
interleukin 8
procalcitonin
taurocholic acid
tumor necrosis factor alpha
acute disease
animal experiment
animal model
animal tissue
article
controlled study
correlation analysis
disease marker
disease severity
edema
evaluation
female
histology
hormone blood level
infection
nonhuman
pancreas necrosis
pancreatitis
protein blood level
rat
Animals
Biological Markers
Calcitonin
Female
Necrosis
Pancreas
Pancreatic Diseases
Protein Precursors
Rats
Rats, Wistar
Reproducibility of Results
Abstract: Background: Infected necrosis in acute pancreatitis is the main factor in determining the prognosis of the disease. Early and accurate diagnosis of infected pancreatic necrosis might decrease mortality. The aim of the present study is to identify a reliable marker for the onset infection in three different experimentally induced pancreatitis models. Methods: Ninety female Wistar albino rats were randomly divided into nine groups. In three different experimental models, including cerulein induced acute oedematous pancreatitis (AEP), sterile pancreatic necrosis due to taurocholate-induced acute pancreatitis (SPN) and infected pancreatic necrosis taurocholate-induced acute pancreatitis (IPN). Serum levels of procalcitonin (PCT), C-reactive protein (CRP), tumour necrosis factor a (TNF-?), interleukin 6 (IL-6) and interleukin 8 (IL-8), amylase were measured. The degree of pancreatic damage also evaluated pathologically. Results: Procalcitonin levels were increased significantly in AEP, SPN and IPN compared to control groups (P < 0.05). PCT and IL-6 level were the highest in the IPN group (P < 0.05). Serum amylase, CRP, TNF-?, IL-2, and IL-8 levels were similar between IPN and SPN groups (P > 0.05), but higher than in other groups. The results of histological evaluation also correlated with the advent of the disease. Conclusion: Procalcitonin and IL-6 acts as reliable acute phase reactant in an experimental model of AEP, SPN and IPN in the rat. PCT and IL-6 combination might be surrogate marker of infected pancreatic necrosis and should be preferred to other markers assay especially in severe pancreatitis.
URI: https://hdl.handle.net/11499/5084
https://doi.org/10.1111/j.1445-2197.2004.03059.x
ISSN: 1445-1433
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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