Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5097
Title: The effect of glutamate and aspartate on myocardial protection at cardiopulmonary bypass
Authors: Özcan, Vefa
Beşo?ul, Y.
Tünerir, B.
Dernek, S.
Erden, T.
Özdemir, C.
Ünal, O.
Keywords: Aspartate
Cardiopulmonary bypass
Glutamate
Myocardial protection
aspartic acid
bicarbonate
citric acid
creatine kinase MB
glucose
glutamic acid
inotropic agent
isotonic solution
magnesium sulfate
potassium
troponin I
age distribution
aorta balloon
aorta clamping
aorta valve replacement
article
blood sampling
cardioplegia
cardiopulmonary bypass
chi square test
cigarette smoking
clinical article
coronary artery bypass surgery
crystalloid
defibrillation
diabetes mellitus
dose response
drug effect
elective surgery
gender
heart infarction
heart protection
human
hypertension
measurement
medical documentation
mitral valve replacement
postoperative period
preoperative care
preoperative period
Student t test
time
Aspartic Acid
Cardioplegic Solutions
Cardiovascular Diseases
Coronary Artery Bypass
Creatine Kinase
Creatine Kinase, MB Form
Female
Glutamic Acid
Heart Arrest, Induced
Humans
Isoenzymes
Male
Middle Aged
Myocardial Reperfusion Injury
Treatment Outcome
Troponin
Abstract: Objective: To determine whether glutamat and aspartat enriched cold crystalloid cardioplegia which was given in antegrade way has any effect on the myocardial protection during cardiopulmonary bypass. Material and Methods: Thirty-four patients who were electively undergone open heart surgery at Osmangazi University Faculty of Medicine, thoracic and cardiovascular surgery department, between March 2001 and May 2001 were included in this study. The patients were divided in two groups, each consisting of 17 patients. In group 1 coronary artery bypass surgery (CABG) was performed in 11 patients, mitral valve replacement (MVR) in 3 patients, aortic valve replacement (AVR) in 1 patient and AVR and MVR in 2 patients. While in group 2 CABG was performed in 13 patients and MVR was done in 4 patients. Group 1 patients received antegrade glutamat and aspartat (15 mmol/L) enriched cold crystalloid cardioplegia and group 2 patients were given cold crystalloid cardioplegia by antegrade route. Age, gender, diabetes mellitus, hypertension, preoperative myocardial infarction, smoking, ejection fraction, aortic cross-clamp time, need to defibrillation, inotropic support, and intraaortic balloon pump were recorded. The levels of cardiac troponin I (cTI) and creatine kinase myocardial band fraction (CK-MB) were measured in arterial blood samples at five different times. Statistical analysis was performed using Student's t-test and Chi-square test. Results: There were no statistically significant differences in cTI and CK-MB values in blood samples taken at 5 different times pre and postoperatively between group 1 and group 2. Conclusion: It is concluded that glutamat and aspartat enriched cold crystalloid cardioplegia does not have any effect on myocardial protection.
URI: https://hdl.handle.net/11499/5097
ISSN: 1302-8723
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection

Files in This Item:
File SizeFormat 
499173ba-0af6-4aa9-9a0b-a05abde406c4.pdf130.82 kBAdobe PDFView/Open
Show full item record



CORE Recommender

SCOPUSTM   
Citations

4
checked on Feb 24, 2024

Page view(s)

40
checked on Aug 24, 2024

Download(s)

32
checked on Aug 24, 2024

Google ScholarTM

Check





Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.