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https://hdl.handle.net/11499/5097
Title: | The effect of glutamate and aspartate on myocardial protection at cardiopulmonary bypass | Authors: | Özcan, Vefa Beşo?ul, Y. Tünerir, B. Dernek, S. Erden, T. Özdemir, C. Ünal, O. |
Keywords: | Aspartate Cardiopulmonary bypass Glutamate Myocardial protection aspartic acid bicarbonate citric acid creatine kinase MB glucose glutamic acid inotropic agent isotonic solution magnesium sulfate potassium troponin I age distribution aorta balloon aorta clamping aorta valve replacement article blood sampling cardioplegia cardiopulmonary bypass chi square test cigarette smoking clinical article coronary artery bypass surgery crystalloid defibrillation diabetes mellitus dose response drug effect elective surgery gender heart infarction heart protection human hypertension measurement medical documentation mitral valve replacement postoperative period preoperative care preoperative period Student t test time Aspartic Acid Cardioplegic Solutions Cardiovascular Diseases Coronary Artery Bypass Creatine Kinase Creatine Kinase, MB Form Female Glutamic Acid Heart Arrest, Induced Humans Isoenzymes Male Middle Aged Myocardial Reperfusion Injury Treatment Outcome Troponin |
Abstract: | Objective: To determine whether glutamat and aspartat enriched cold crystalloid cardioplegia which was given in antegrade way has any effect on the myocardial protection during cardiopulmonary bypass. Material and Methods: Thirty-four patients who were electively undergone open heart surgery at Osmangazi University Faculty of Medicine, thoracic and cardiovascular surgery department, between March 2001 and May 2001 were included in this study. The patients were divided in two groups, each consisting of 17 patients. In group 1 coronary artery bypass surgery (CABG) was performed in 11 patients, mitral valve replacement (MVR) in 3 patients, aortic valve replacement (AVR) in 1 patient and AVR and MVR in 2 patients. While in group 2 CABG was performed in 13 patients and MVR was done in 4 patients. Group 1 patients received antegrade glutamat and aspartat (15 mmol/L) enriched cold crystalloid cardioplegia and group 2 patients were given cold crystalloid cardioplegia by antegrade route. Age, gender, diabetes mellitus, hypertension, preoperative myocardial infarction, smoking, ejection fraction, aortic cross-clamp time, need to defibrillation, inotropic support, and intraaortic balloon pump were recorded. The levels of cardiac troponin I (cTI) and creatine kinase myocardial band fraction (CK-MB) were measured in arterial blood samples at five different times. Statistical analysis was performed using Student's t-test and Chi-square test. Results: There were no statistically significant differences in cTI and CK-MB values in blood samples taken at 5 different times pre and postoperatively between group 1 and group 2. Conclusion: It is concluded that glutamat and aspartat enriched cold crystalloid cardioplegia does not have any effect on myocardial protection. | URI: | https://hdl.handle.net/11499/5097 | ISSN: | 1302-8723 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection |
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