Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/51022
Title: A multicenter retrospective analysis of patients with nasopharyngeal carcinoma treated in IMRT era from a nonendemic population: Turkish Society for Radiation Oncology Head and Neck Cancer Group Study (TROD 01-001)
Authors: Yıldırım, Halil Cumhur
Kupik, Gülnihan Eren
Mustafayev, Teuta Zoto
Berber, Tanju
Yavuz, Berrin
Çetinayak, Oğuz
Akagündüz, Özlem
Bicakci, Beyhan Ceylaner
Arslan, Suheyla Aytac
Soykut, Ela Delikgoz
Gundog, Mete
Figen, Metin
Teke, Fatma
Canyilmaz, Emine
Birgi, Sumerya Duru
Duzova, Mursel
Igdem, Sefik
Abakay, Candan Demiroz
Atasoy, Beste
Kaydihan, Nuri
Parvizi, Murtaza
Uslu, Gonca Hanedan
Saginc, Halil
Akman, Fadime
Ozyar, Enis
Keywords: chemoradiotherapy
EBV-DNA
intensity-modulated radiotherapy
nasopharyngeal carcinoma
nonendemic
Intensity-Modulated Radiotherapy
Ajcc/Uicc Staging System
Concurrent Chemoradiotherapy
8th Edition
Chemotherapy
Dna
Validation
Worldwide
Outcomes
Trials
Publisher: Wiley
Abstract: BackgroundWe aimed to evaluate patients with nasopharyngeal carcinoma (NPC) in a nonendemic population. MethodsIn a national, retrospective, multicenteric study, 563 patients treated with intensity modulated radiotherapy at 22 centers between 2015 and 2020 were analyzed. ResultsMedian age was 48 (9-83), age distribution was bimodal, 74.1% were male, and 78.7% were stage III-IVA. Keratinizing and undifferentiated carcinoma rates were 3.9% and 81.2%. Patients were treated with concomitant chemoradiotherapy (48.9%), or radiotherapy combined with induction chemotherapy (25%) or adjuvant chemotherapy (19.5%). After 34 (6-78) months follow-up, 8.2% locoregional and 8% distant relapse were observed. Three-year overall survival was 89.5% and was lower in patients with age >= 50, male sex, keratinizing histology, T4, N3 and advanced stage (III-IVA). ConclusionsPatients with NPC in Turkey have mixed clinical features of both east and west. Survival outcomes are comparable to other reported series; however, the rate of distant metastases seems to be lower.
URI: https://doi.org/10.1002/hed.27333
https://hdl.handle.net/11499/51022
ISSN: 1043-3074
1097-0347
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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