Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/51033
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dc.contributor.authorÖztürk, Şevval-
dc.contributor.authorCüneyit, İbrahim-
dc.contributor.authorAltuntaş, Fatih-
dc.contributor.authorKaragür, Ege Rıza-
dc.contributor.authorCort Dönmez, Ayşegül-
dc.contributor.authorOcak, Mert-
dc.contributor.authorÜnal, Mustafa-
dc.contributor.authorSarikanat, Mehmet-
dc.contributor.authorDonmez, Baris Ozgur-
dc.date.accessioned2023-06-13T19:08:07Z-
dc.date.available2023-06-13T19:08:07Z-
dc.date.issued2023-
dc.identifier.issn0914-8779-
dc.identifier.issn1435-5604-
dc.identifier.urihttps://doi.org/10.1007/s00774-023-01416-z-
dc.identifier.urihttps://hdl.handle.net/11499/51033-
dc.description.abstractIntroductionOsteoporosis is a major health problem that is very common worldwide and is characterized by both low bone density and deterioration in bone quality. New treatment options without side effects have become an active area of research in recent years. This study was designed to investigate the preventive effects of resveratrol on bone quality deterioration caused by ovariectomy.Materials and MethodsSixty rats were randomly divided into five groups (12 animals per group): Control, Sham-operated (SHAM), ovariectomized (OVX), OVX + Resveratrol-40 mg/kg/day (OVX + Res40), OVX + Resveratrol-80 mg/kg/day (OVX + Res80). Resveratrol was administered by oral gavage (40 and 80 mg/kg/day) for ten weeks. Micro-CT measurements, biomechanical testing, Raman spectroscopy analysis, and RT-PCR analysis were performed. ALP, OCN, TAS, and TOS levels were also measured from blood serum.ResultsBone strength, bone volume/total volume, trabecular volume, and trabecular thickness were higher in the OVX + RES-80 group than in the OVX group. Resveratrol increased osteogenic differentiation, as the expression of osteogenic markers ALP, Col1A1, Runx2, OPG, OCN increased in both OVX + RES-80 and OVX + RES-40 groups compared to the OVX group. 80 mg/kg/day resveratrol administration decreased the levels of ALP, OCN and TOS in ovariectomized rats. Raman spectroscopy findings showed a preventive effect of resveratrol administration against ovariectomy-induced deterioration in biophysiochemical properties of bone tissue.ConclusionThis study revealed that administration of different doses of 80 mg/kg/day and 40 mg/kg/day of resveratrol had protective effects on bone quality deterioration caused by ovariectomy.en_US
dc.language.isoenen_US
dc.publisherSpringer Japan Kken_US
dc.relation.ispartofJournal of Bone and Mineral Metabolismen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOsteoporosisen_US
dc.subjectResveratrolen_US
dc.subjectOvariectomyen_US
dc.subjectBone biologyen_US
dc.subjectRaman spectroscopyen_US
dc.subjectOsteoporosisen_US
dc.subjectSupplementationen_US
dc.subjectFragilityen_US
dc.subjectHormoneen_US
dc.subjectMepeen_US
dc.subjectRatsen_US
dc.titleResveratrol prevents ovariectomy-induced bone quality deterioration by improving the microarchitectural and biophysicochemical properties of boneen_US
dc.typeArticleen_US
dc.departmentPamukkale Universityen_US
dc.authoridAltıntaş, Fatih/0000-0001-8779-0110-
dc.authoridCort Donmez, Aysegul/0000-0001-8946-7173-
dc.identifier.doi10.1007/s00774-023-01416-z-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid58174451300-
dc.authorscopusid57204310977-
dc.authorscopusid58175150500-
dc.authorscopusid55968558200-
dc.authorscopusid57940978300-
dc.authorscopusid57193904264-
dc.authorscopusid56303951600-
dc.authorwosidAltıntaş, Fatih/ABF-5161-2021-
dc.authorwosidCort Donmez, Aysegul/HJY-8866-2023-
dc.identifier.pmid37031330en_US
dc.identifier.scopus2-s2.0-85152073859en_US
dc.identifier.wosWOS:000967277900001en_US
dc.institutionauthor-
dc.identifier.scopusqualityQ2-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.grantfulltextnone-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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