Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/51206
Title: Cognitive outcomes of transcranial magnetic stimulation in treatment-resistant depression: a randomized controlled study
Authors: Yıldız, Tahir
Kalkan Oğuzhanoğlu, Nalan
Topak, Osman Zulkif
Keywords: Depression
transcranial magnetic stimulation
neurocognitive functions
Executive Function
Disorder
Performance
Symptoms
Deficits
Tms
Schizophrenia
Metaanalysis
Association
Reliability
Publisher: Scientific And Technological Research Council Turkey
Abstract: Background/aim: Major depressive disorder (MDD) is a significant cause of workforce loss, and is associated with cognitive impairments which can continue even after the elimination of mood and behavioural symptoms. The aim of this study was to investigate the benefit of transcranial magnetic stimulation (TMS) on cognitive functions in treatment resistant depression. Materials and methods: This randomised controlled clinical trial was conducted at a university hospital, department of psychiatry (tertiary centre) between October 2019 and July 2020. The study included 30 patients with depressive disorder, aged 18-50 years, who did not respond to at least two antidepressant medications for at least 8 weeks (one drug used was serotonin norepinephrine reuptake inhibitor [SNRI]; and 15 healthy control subjects. The patients were separated into two equal groups in a double-blind, random man-ner, and 20 sessions of repeated TMS was applied to one group, and 20 sessions of sham TMS to the other. The Montgomery Asberg Depression Scale (MADRS), Hamilton Depression Rating Scale (HAM-D), Stroop test, Wisconsin Card Sorting Test (WCST), Digit Span Test (DST), Trail Making Test A-B, and Verbal Memory Processes Test (VMPT) were applied to the patients before and after the TMS procedure. Results: The decrease in the HAM-D score was greater in the active magnetic stimulation (25 trains, 10 Hz, 110% motor threshold intensity) group, and with the exception of verbal memory processes, better performance was obtained by the active magnetic stimulation group than the sham group in the cognitive function tests. Conclusion: TMS was seen toimprove the cognitive defects present in the active phase of treatment-resistant depression, and therefore TMS could provide early improvement in cognitive functions in clinical use.
URI: https://doi.org/10.55730/1300-0144.5580
https://search.trdizin.gov.tr/yayin/detay/1160840
https://hdl.handle.net/11499/51206
ISSN: 1300-0144
1303-6165
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File SizeFormat 
Cognitive outcomes of transcranial magnetic stimulation in treatm.pdf617.22 kBAdobe PDFView/Open
Show full item record



CORE Recommender

SCOPUSTM   
Citations

6
checked on Dec 7, 2024

WEB OF SCIENCETM
Citations

7
checked on Dec 11, 2024

Page view(s)

162
checked on Aug 24, 2024

Download(s)

22
checked on Aug 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.