Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/51247
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dc.contributor.authorSemiz, Gürkan-
dc.contributor.authorMutlu, D.-
dc.contributor.authorGünal, Batıkan-
dc.contributor.authorSemiz, Aslı-
dc.contributor.authorArslan, Şevki-
dc.date.accessioned2023-06-13T19:12:51Z-
dc.date.available2023-06-13T19:12:51Z-
dc.date.issued2023-
dc.identifier.issn2210-8033-
dc.identifier.urihttps://doi.org/10.1016/j.hermed.2023.100664-
dc.identifier.urihttps://hdl.handle.net/11499/51247-
dc.description.abstractIntroduction: Species of the Salvia genus are aromatic herbs and traditionally used for many medicinal purposes in Anatolia. The genus has produced an extraordinarily large number of beneficial secondary metabolites belonging to numerous chemical groups. Salvia pisidica is an endemic plant of southwest Anatolia, the dried parts of which are used as herbal tea and local materia medica. Methods: The composition of endemic S. pisidica essential oil was determined through GC-MS studies. In vitro cytotoxicity activity and apoptosis analysis were investigated by MTT assay, q-PCR and Annexin V staining experiments. Results: Our results showed that 1,8 cineole (19.15 %) camphor (18.12 %) and γ-gurjunene (8.58 %) were the major constituents of the essential oil. It showed cytotoxic effects on the human breast cancer MCF-7, colon carcinoma Caco-2, hepatocyte carcinoma HepG2, and prostate carcinoma LnCap. The results of q-PCR and image-cytometer analysis showed that the essential oil caused induction of apoptosis by intrinsic and extrinsic pathways in all cancer cell lines. Conclusion: S. pisidica essential oil demonstrates considerable cytotoxic activity due to an apoptosis-related mechanism, suggesting that their bioactive components could be used as natural anticancer substances. © 2023 Elsevier GmbHen_US
dc.description.sponsorshipPamukkale Üniversitesi, PAÜ: 2018KRM011en_US
dc.description.sponsorshipOur study was supported in part by the Scientific Research Coordination Unit of Pamukkale University under the project number 2018KRM011 .en_US
dc.language.isoenen_US
dc.publisherElsevier GmbHen_US
dc.relation.ispartofJournal of Herbal Medicineen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptoticen_US
dc.subjectCytotoxicen_US
dc.subjectEssential oilen_US
dc.subjectGC-MSen_US
dc.subjectSalvia pisidicaen_US
dc.subject4 cymene 7 olen_US
dc.subjectabsintholen_US
dc.subjectalpha cubebeneen_US
dc.subjectalpha gualeneen_US
dc.subjectalpha gurjuneneen_US
dc.subjectaromadendreneen_US
dc.subjectbeta humuleneen_US
dc.subjectbeta pineneen_US
dc.subjectborneolen_US
dc.subjectcadaleneen_US
dc.subjectcampheneen_US
dc.subjectcamphoren_US
dc.subjectcarvacrolen_US
dc.subjectcarveolen_US
dc.subjectcarvoneen_US
dc.subjectcaryaphyllene oxideen_US
dc.subjectcineoleen_US
dc.subjectcopaeneen_US
dc.subjectcuminaldehydeen_US
dc.subjectdelta cadineneen_US
dc.subjectessential oilen_US
dc.subjecteugenolen_US
dc.subjectgamma cadineneen_US
dc.subjectgamma elemeneen_US
dc.subjectgamma gurjuneneen_US
dc.subjectjasmoneen_US
dc.subjectlimoneneen_US
dc.subjectlipocortin 5en_US
dc.subjectlongifoleneen_US
dc.subjectmyceneen_US
dc.subjectmyrtenolen_US
dc.subjectocimeneen_US
dc.subjectphellendralen_US
dc.subjectpineneen_US
dc.subjectpinocarvoneen_US
dc.subjectpiperitoneen_US
dc.subjectplant medicinal producten_US
dc.subjectterpenoid derivativeen_US
dc.subjectterpineneen_US
dc.subjectterpineolen_US
dc.subjectunclassified drugen_US
dc.subjectverbenoneen_US
dc.subjectviridiflorolen_US
dc.subjectantineoplastic activityen_US
dc.subjectantitumorigenic activityen_US
dc.subjectapoptosisen_US
dc.subjectArticleen_US
dc.subjectbreast cancer cell lineen_US
dc.subjectCaco-2 cell lineen_US
dc.subjectcancer cell lineen_US
dc.subjectchemical compositionen_US
dc.subjectcolon carcinoma cell lineen_US
dc.subjectcontrolled studyen_US
dc.subjectcytotoxicityen_US
dc.subjectdrug determinationen_US
dc.subjectembryoen_US
dc.subjectHEK293 cell lineen_US
dc.subjecthepatocellular carcinoma cell lineen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectimage cytometryen_US
dc.subjectin vitro studyen_US
dc.subjectintrinsic activityen_US
dc.subjectLNCaP cell lineen_US
dc.subjectmass fragmentographyen_US
dc.subjectMCF-7 cell lineen_US
dc.subjectMTT assayen_US
dc.subjectprostate carcinoma cell lineen_US
dc.subjectreal time polymerase chain reactionen_US
dc.subjectSalviaen_US
dc.subjectSalvia pisidicaen_US
dc.titleThe anticancer effect of Salvia pisidica essential oil through promotion intrinsic and extrinsic apoptosis pathways in human cancer cell linesen_US
dc.typeArticleen_US
dc.identifier.volume39en_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.1016/j.hermed.2023.100664-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid56033283900-
dc.authorscopusid57212511655-
dc.authorscopusid57224679207-
dc.authorscopusid15846728700-
dc.authorscopusid8684142100-
dc.identifier.scopus2-s2.0-85159603044en_US
dc.identifier.wosWOS:001007292200001en_US
dc.institutionauthor…-
dc.identifier.scopusqualityQ2-
item.languageiso639-1en-
item.openairetypeArticle-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept17.02. Biology-
crisitem.author.dept17.02. Biology-
crisitem.author.dept20.03. Biomedical Engineering-
crisitem.author.dept17.02. Biology-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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