The effects of swimming exercise and detraining on hemorheological parameters and oxidative stress in rats with metabolic syndrome

Abstract

Background: Moderate-intensity aerobic exercise training with high frequency is recommended in metabolic syndrome (MetS). We aimed to investigate the effects of swimming and subsequent detraining on hemorheology and oxidative stress in MetS. Material and methods: A total of 80 rats were used. MetS was induced by a 4 mg/g monosodium glutamate (MSG) injection to rats on days 0–10, every other day. Swimming exercise training was applied 30 minutes, 3 days/week, with a 5% body weight load, for 18 weeks. Detraining was applied for 8 weeks. Erythrocyte deformability was measured with an ektacytometer, whole blood viscosity (WBV) by a cone-plate viscometer, total oxidant-antioxidant capacity (TOS-TAS) were measured by commercial kits. Results: Exercise resulted in an increment of HDL in rats with MetS, which was not reversed by detraining. Swimming decreased HOMA-IR score in MetS. Detraining caused an increase in WBV in healthy rats. The exercise applied resulted in an increase in TAS in both healthy and MetS rats. Conclusion: We suggest that swimming may be beneficial in MetS and may contribute positively to the prevention of the development of possible complications by increasing TAS. Since some of the gains of exercise training are reversed by detraining, lifetime exercise training may be recommended. © 2023 Société francophone nutrition clinique et métabolisme (SFNCM)