Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/51401
Title: Investigation of neuraminidase 1 gene association in Henoch-Schönlein Purpura (HSP) with renal involvement
Authors: Yılmaz, Nezihe Bilge
Ertan, Pelin
Yüksel, Selçuk
Neşe, Nalan
Horasan, Gönül Dinç
Berdeli, Afig Hüseyinov
Abstract: Objectives: HSP is a common small vessel vasculitis. It is the most common cause of non-thrombocytopenic purpura in childhood. The role of genes in etiopathogenesis of the disease, which has not yet been clearly elucidated, is being emphasized. Many genes called sialidases are being studied and is thought that the NEU1 gene may be particularly important in the etiopathogenesis of HSP. The aim of this study is to investigate the role of the NEU1 gene in the etiopathogenesis of HSP and its relation to renal involvement.Materials and methods: Fifty patients followed in the Celal Bayar University Hafsa Sultan Hospital Pediatric Nephrology Department, with the diagnosis of HSP renal involvement were included into the study. For the control group, age and gender matched 50 cases were accepted among the outpatients admitted to Pediatric Department without any chronic diseases. NEU1 gene mutation analysis was performed in blood samples of both patient and control groups by using the Sanger DNA sequencing method.Results: NEU1 genetic mutation was not detected in any HSP patient with renal involvement and control group. Conclusion: In our study, the NEU 1 gene was not found to be associated with HSP nephritis. No changes were detected in the investigated regions of the NEU1 gene. 
URI: https://doi.org/10.31362/patd.1021975
https://search.trdizin.gov.tr/yayin/detay/1163615
https://hdl.handle.net/11499/51401
ISSN: 1309-9833
1308-0865
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection

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