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https://hdl.handle.net/11499/51428
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DC Field | Value | Language |
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dc.contributor.author | Doğan, Muhammed Fatih | - |
dc.contributor.author | Seçme, Mücahit | - |
dc.contributor.author | Şahin, Yasemin | - |
dc.contributor.author | Çiftçi, Osman | - |
dc.date.accessioned | 2023-06-13T19:17:42Z | - |
dc.date.available | 2023-06-13T19:17:42Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 1309-9833 | - |
dc.identifier.issn | 1308-0865 | - |
dc.identifier.uri | https://doi.org/10.31362/patd.1172097 | - |
dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/1163590 | - |
dc.identifier.uri | https://hdl.handle.net/11499/51428 | - |
dc.description.abstract | Purpose: Endometrial cancer is one of the most common gynecological cancers in the world. Glabridin is a main isoflavone in Glycyrrhiza glabra (licorice) root. It has several therapeutic effects such as anti-proliferative and anti-inflammatory. Long non-coding RNAs (LncRNAs) play a role in a variety of cellular processes, and their abnormal expression may contribute to tumor development and progression. In this study, the effects of glabridin on LncRNAs gene expression and viability of HEC-1B human endometrial cancer cell lines have been investigated. Materials and methods: Glabridin was applied to HEC-1B cells in concentrations of 1 μM, 10 μM, 20 μM, 40 μM, 60 μM, and 80 μM. Glabridin's effect on HEC-1B cell proliferation was also evaluated using MTS assay. Expression profiles of LncRNAs such as H19, RNU43, LNC-MYC-3:1 and ABCC5-AS1:1 were determined by real-time PCR. Results: Glabridin reduced the viability of HEC-1B cells in a time- and dose-dependent manner. The half maximal inhibitory concentration (IC50) dose in HEC-1B cells was detected to be 21.32 μM and 13.5 μM at the 24th and 48 hours, respectively. Glabridin has been observed to cause a significant decrease in the expression of H19 and RNU43 while increasing in the expression of LNC-MYC-3:1 and ABCC5-AS1:1. Conclusion: Glabridin could induce HEC-1B cell death by regulating LncRNAs expression. As a result, glabridin is a potential candidate for a more effective therapeutic agent against human endometrial cancer. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Pamukkale Tıp Dergisi | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.title | Effects of glabridin on cell proliferation and long non-coding RNA expression in HEC-1B cells | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 16 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 59 | en_US |
dc.identifier.endpage | 65 | en_US |
dc.department | Pamukkale University | en_US |
dc.identifier.doi | 10.31362/patd.1172097 | - |
dc.relation.publicationcategory | Makale - Uluslararasi Hakemli Dergi - Kurum Ögretim Elemani | en_US |
dc.identifier.scopus | 2-s2.0-85160730450 | en_US |
dc.identifier.trdizinid | 1163590 | en_US |
dc.institutionauthor | … | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection |
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Effects-of-glabridin-on-cell-proliferation-and-long-noncoding-RNA-expression-in-HEC1B-cellsPamukkale-Medical-Journal.pdf | 740.28 kB | Adobe PDF | View/Open |
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