Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5143
Title: Non-NMDA mechanism in the inhibition of cellular apoptosis and memory impairment induced by repeated ischemia in rats
Authors: Iwasaki, K.
Chung, E.-H.
Egashira, N.
Hatip-Al-Khatib, I.
Mishima, K.
Egawa, T.
Irie, K.
Keywords: Apoptosis
MK-801
Repeated ischemia
Spatial memory
YM-90K
6 (1 imidazolyl) 7 nitro 2,3 quinoxalinedione
6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione
amino acid receptor blocking agent
AMPA receptor
AMPA receptor antagonist
dizocilpine
dizocilpine maleate
n methyl dextro aspartic acid receptor
n methyl dextro aspartic acid receptor blocking agent
neuroprotective agent
quinoxaline derivative
unclassified drug
animal
animal experiment
animal model
animal tissue
apoptosis
article
brain cell
brain ischemia
brain perfusion
cell count
comparative study
controlled study
convalescence
disease model
drug effect
hippocampus
male
maze test
memory disorder
metabolism
nerve cell
nerve cell necrosis
nerve degeneration
neuroprotection
nonhuman
pathophysiology
physiology
priority journal
quantitative analysis
rat
rat strain
regulatory mechanism
reperfusion
reperfusion injury
spatial memory
Publisher: Elsevier
Abstract: The spatial memory impairment and expression of apoptotic cells in hippocampal CA1 cells were investigated in rats using single and repeated ischemia models. The neuroprotective and memory-improving effect of YM-90K, an ?-amino-3-hydroxy-5-methyl-isoxazole-4-propionate (AMPA) receptor antagonist, was compared to MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist. Twice-repeated ischemia, but not single ischemia, impaired the spatial memory and increased expression of apoptotic cells. YM-90K, given before and 6 h after the second reperfusion, significantly improved the memory and reduced the apoptotic cells 7 days after the second reperfusion in repeated ischemia. MK-801 neither improved the spatial memory nor reduced apoptotic cells. The present study showed that delayed expression of apoptotic cells is mediated by mechanisms involving AMPA receptors, but not by NMDA receptor, during the late phase after reperfusion. YM-90K could provide neuroprotective activity and improve the spatial memory impaired by repeated ischemia. © 2003 Elsevier B.V. All rights reserved.
URI: https://hdl.handle.net/11499/5143
https://doi.org/10.1016/j.brainres.2003.09.064
ISSN: 0006-8993
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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