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https://hdl.handle.net/11499/5143
Title: | Non-NMDA mechanism in the inhibition of cellular apoptosis and memory impairment induced by repeated ischemia in rats | Authors: | Iwasaki, K. Chung, E.-H. Egashira, N. Hatip-Al-Khatib, I. Mishima, K. Egawa, T. Irie, K. |
Keywords: | Apoptosis MK-801 Repeated ischemia Spatial memory YM-90K 6 (1 imidazolyl) 7 nitro 2,3 quinoxalinedione 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione amino acid receptor blocking agent AMPA receptor AMPA receptor antagonist dizocilpine dizocilpine maleate n methyl dextro aspartic acid receptor n methyl dextro aspartic acid receptor blocking agent neuroprotective agent quinoxaline derivative unclassified drug animal animal experiment animal model animal tissue apoptosis article brain cell brain ischemia brain perfusion cell count comparative study controlled study convalescence disease model drug effect hippocampus male maze test memory disorder metabolism nerve cell nerve cell necrosis nerve degeneration neuroprotection nonhuman pathophysiology physiology priority journal quantitative analysis rat rat strain regulatory mechanism reperfusion reperfusion injury spatial memory |
Publisher: | Elsevier | Abstract: | The spatial memory impairment and expression of apoptotic cells in hippocampal CA1 cells were investigated in rats using single and repeated ischemia models. The neuroprotective and memory-improving effect of YM-90K, an ?-amino-3-hydroxy-5-methyl-isoxazole-4-propionate (AMPA) receptor antagonist, was compared to MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist. Twice-repeated ischemia, but not single ischemia, impaired the spatial memory and increased expression of apoptotic cells. YM-90K, given before and 6 h after the second reperfusion, significantly improved the memory and reduced the apoptotic cells 7 days after the second reperfusion in repeated ischemia. MK-801 neither improved the spatial memory nor reduced apoptotic cells. The present study showed that delayed expression of apoptotic cells is mediated by mechanisms involving AMPA receptors, but not by NMDA receptor, during the late phase after reperfusion. YM-90K could provide neuroprotective activity and improve the spatial memory impaired by repeated ischemia. © 2003 Elsevier B.V. All rights reserved. | URI: | https://hdl.handle.net/11499/5143 https://doi.org/10.1016/j.brainres.2003.09.064 |
ISSN: | 0006-8993 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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