Predictive value of serum vitamin B12 elevation in acute leukemia

Abstract

Purpose: In this study; we sought to assess whether elevated vitamin B12 levels during the course of diagnosis might be a predictor of acute leukemias.Materials and method: The study was prepared by retrospectively evaluating the anamnesis and laboratory information of 95 patients diagnosed with acute leukemia (AML or ALL). Those who had any of the conditions clearly known to increase vitamin B12 levels by scanning their anamnesis and laboratory information were not included in the study.Results: In total, it was observed that serum vitamin B12 level at the time of diagnosis was above the normal reference range (>771ng/L) in 36% of the patients. In the survival analysis performed to evaluate the effect of high serum vitamin B12 levels on prognosis, no statistically significant difference was found.Conclusion: The data we obtained from this study; shows that high serum vitamin B12 levels may have predictive value for acute leukemia.