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https://hdl.handle.net/11499/51439
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DC Field | Value | Language |
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dc.contributor.author | Gökçe, Kadri | - |
dc.contributor.author | Sabırlı, Ramazan | - |
dc.contributor.author | Köseler, Aylin | - |
dc.contributor.author | Türkçüer, İbrahim | - |
dc.contributor.author | Yılmaz, Atakan | - |
dc.date.accessioned | 2023-06-13T19:17:43Z | - |
dc.date.available | 2023-06-13T19:17:43Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 1309-9833 | - |
dc.identifier.issn | 1308-0865 | - |
dc.identifier.uri | https://doi.org/10.31362/patd.886194 | - |
dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/1163561 | - |
dc.identifier.uri | https://hdl.handle.net/11499/51439 | - |
dc.description.abstract | Introduction: The rupture of atherosclerotic plaques is caused by the impact of matrix metalloproteinases (MMPs) upon the local fibrous valve and so might convert a chronic disease to a myocardial infarction, ultimately leading to instant death. Angiotensin converting enzyme (ACE) is actively engaged in the pathogenesis of ischemic heart disease. This study tries to unravel whether/how ACE and MMP-2 gene polymorphism contributes to the occurrence of Coronary Artery Disease (CAD). Materials and methods: A total of 300 individuals (100 healthy/200 patients) were included in the study. A PCR-RFLP method was utilized for ACE gene I/D and DNA sequencing MMP-2 (-1306 C/T) polymorphisms. Results: The ACE-1 gene D/D, I/D and I/I genotype frequency of the CAD cohort was 50%, 29%, and 21%, respectively whereas that of the healthy control cohort was 37%, 45% and 18%, respectively. Our findings indicate that the groups differed significantly in relation to the ACE-1 genotypes (p=0.021). The frequencies of ACE-1 gene allele I and D in both cohorts did not reveal a significant difference (p=0.314). In addition, the two groups did not manifest MMP-2 (rs243865) gene polymorphism. Conclusion: The association between MMP-2 gene polymorphism and CAD is too weak to suggest a conclusive evidence. The I/D genotype frequency remained higher in the healthy individuals than in the CAD cohort, while in the CAD group D/D genotype was more frequently than control group. Finally, the patients with D/D genotype tend to bear greater risk for cardiovascular diseases. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Pamukkale Tıp Dergisi | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.title | Matrix metalloproteinase-2 and angiotensin-1 gene polymorphisms in patient who have coronary artery disease | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 15 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 29 | en_US |
dc.identifier.endpage | 36 | en_US |
dc.department | Pamukkale University | en_US |
dc.identifier.doi | 10.31362/patd.886194 | - |
dc.relation.publicationcategory | Makale - Uluslararasi Hakemli Dergi - Kurum Ögretim Elemani | en_US |
dc.identifier.scopus | 2-s2.0-85160693606 | en_US |
dc.identifier.trdizinid | 1163561 | en_US |
dc.institutionauthor | … | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection |
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File | Size | Format | |
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Matrix metalloproteinase-2.pdf | 750.06 kB | Adobe PDF | View/Open |
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