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DC Field | Value | Language |
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dc.contributor.author | Göktaş Aydın, Sabin | - |
dc.contributor.author | Çakan Demirel, Burçin | - |
dc.contributor.author | Bilici, Ahmet | - |
dc.contributor.author | Yılmaz, Cansu | - |
dc.contributor.author | Topçu, Atakan | - |
dc.contributor.author | Aykan, Musa Barış | - |
dc.contributor.author | Kahraman, Seda | - |
dc.contributor.author | Atçı, Muhammed Mustafa | - |
dc.contributor.author | Akbıyık, Ilgın | - |
dc.contributor.author | Akgül, Fahri | - |
dc.contributor.author | Ölmez, Ömer Fatih | - |
dc.contributor.author | Aydın, Ahmet | - |
dc.date.accessioned | 2023-06-13T19:19:15Z | - |
dc.date.available | 2023-06-13T19:19:15Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 0304-596X | - |
dc.identifier.issn | 2148-7669 | - |
dc.identifier.uri | https://doi.org/10.5505/aot.2023.03708 | - |
dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/1177946 | - |
dc.identifier.uri | https://hdl.handle.net/11499/51500 | - |
dc.description.abstract | Introduction: There is a lack of evidence of the outcomes in elderly patients advanced stage biliary tract cancer due to the patients aged over 65 years are less than 25% in many prospective trials. We designed a retrospective multicenter study to evaluate the factors affecting treatment and survival in elderly patients with advanced-stage biliary tract cancer. Materials and methods: A total of 116 patients with advanced stage biliary tract cancer aged ≥65 years were included, and the treatment responses, survival, and toxicity rates were evaluated with respect to age groups Results: There was no significant difference between age and response to treatment, survival, or toxicity. The median progression-free survival and overall survival were 5.3, and 11.8 months respectively. Multivariate analysis indicated that ECOG PS (p<0.001 CI95% 1.5-3.7) and PNI (p<0.001 CI 95% 0.14-0.41) were significant independent prognostic factors for PFS. The independent prognostic factors for OS were choice of frontline regimen, NLR and PNI (p=0.007 CI 95% 0.71 – 0.94, p=0.006 CI 95% 1.2 – 3.1, p=0.001 CI 95% 0.35 – 0.91, respectively). Discussion: This study confirms the general prognostic relevance of inflammatory parameters and the importance of frontline treatment in elderly patients with advanced-stage biliary tract tumors. Additionally, getting older does not indicate that treatment will be avoided or that they will have a worse prognosis and suffer from more toxicities. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | ACTA ONCOLOGICA TURCICA | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.title | The Optimal Treatment Approaches and Prognostic Factors in Elderly Patients with Advanced Stage Biliary Tract Tumors | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 56 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 81 | en_US |
dc.identifier.endpage | 89 | en_US |
dc.department | Pamukkale University | en_US |
dc.identifier.doi | 10.5505/aot.2023.03708 | - |
dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.trdizinid | 1177946 | en_US |
dc.institutionauthor | … | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Article | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection |
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document - 2024-04-18T144240.374.pdf | 389.27 kB | Adobe PDF | View/Open |
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