Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/51500
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dc.contributor.authorGöktaş Aydın, Sabin-
dc.contributor.authorÇakan Demirel, Burçin-
dc.contributor.authorBilici, Ahmet-
dc.contributor.authorYılmaz, Cansu-
dc.contributor.authorTopçu, Atakan-
dc.contributor.authorAykan, Musa Barış-
dc.contributor.authorKahraman, Seda-
dc.contributor.authorAtçı, Muhammed Mustafa-
dc.contributor.authorAkbıyık, Ilgın-
dc.contributor.authorAkgül, Fahri-
dc.contributor.authorÖlmez, Ömer Fatih-
dc.contributor.authorAydın, Ahmet-
dc.date.accessioned2023-06-13T19:19:15Z-
dc.date.available2023-06-13T19:19:15Z-
dc.date.issued2023-
dc.identifier.issn0304-596X-
dc.identifier.issn2148-7669-
dc.identifier.urihttps://doi.org/10.5505/aot.2023.03708-
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1177946-
dc.identifier.urihttps://hdl.handle.net/11499/51500-
dc.description.abstractIntroduction: There is a lack of evidence of the outcomes in elderly patients advanced stage biliary tract cancer due to the patients aged over 65 years are less than 25% in many prospective trials. We designed a retrospective multicenter study to evaluate the factors affecting treatment and survival in elderly patients with advanced-stage biliary tract cancer. Materials and methods: A total of 116 patients with advanced stage biliary tract cancer aged ≥65 years were included, and the treatment responses, survival, and toxicity rates were evaluated with respect to age groups Results: There was no significant difference between age and response to treatment, survival, or toxicity. The median progression-free survival and overall survival were 5.3, and 11.8 months respectively. Multivariate analysis indicated that ECOG PS (p<0.001 CI95% 1.5-3.7) and PNI (p<0.001 CI 95% 0.14-0.41) were significant independent prognostic factors for PFS. The independent prognostic factors for OS were choice of frontline regimen, NLR and PNI (p=0.007 CI 95% 0.71 – 0.94, p=0.006 CI 95% 1.2 – 3.1, p=0.001 CI 95% 0.35 – 0.91, respectively). Discussion: This study confirms the general prognostic relevance of inflammatory parameters and the importance of frontline treatment in elderly patients with advanced-stage biliary tract tumors. Additionally, getting older does not indicate that treatment will be avoided or that they will have a worse prognosis and suffer from more toxicities.en_US
dc.language.isoenen_US
dc.relation.ispartofACTA ONCOLOGICA TURCICAen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe Optimal Treatment Approaches and Prognostic Factors in Elderly Patients with Advanced Stage Biliary Tract Tumorsen_US
dc.typeArticleen_US
dc.identifier.volume56en_US
dc.identifier.issue1en_US
dc.identifier.startpage81en_US
dc.identifier.endpage89en_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.5505/aot.2023.03708-
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.trdizinid1177946en_US
dc.institutionauthor-
item.grantfulltextopen-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
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