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https://hdl.handle.net/11499/51525
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DC Field | Value | Language |
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dc.contributor.author | Barış Moğul, İkbal Cansu | - |
dc.contributor.author | Dodurga, Yavuz | - |
dc.contributor.author | Pars Uygur, Ecem | - |
dc.contributor.author | Yaylalı, Güzin Fidan | - |
dc.contributor.author | Akdağ, Zeliha | - |
dc.date.accessioned | 2023-06-13T19:19:17Z | - |
dc.date.available | 2023-06-13T19:19:17Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 1309-9833 | - |
dc.identifier.issn | 1308-0865 | - |
dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/1163665 | - |
dc.identifier.uri | https://hdl.handle.net/11499/51525 | - |
dc.description.abstract | Purpose: Obesity is a medical condition caused by excess body fat that accumulates at a level that can have a detrimental impact on health. Altered glucose and lipid metabolism, low-grade chronic inflammation controbutes to the pathogenesis of obesity and obesity-related metabolic dysfunction. In our study, we purposed to specify the apelin, kynurenine, IL-4, IL-10, IL-12, TNF-α protein levels in obese individuals and healthy control groups, and to research the possible relationship between clinical parameters with the data to be obtained. Materials and methods: The levels of apelin, kynurenine, IL-4, IL-10, IL-12, TNF-α in serum/plasma samples were determined with enzyme-linked immunosorbent assay. Absorbance of the samples were measured on a microplate reader spectrophotometrically at a wavelength of 450 nm.Results: The levels of kynurenine, IL-4, and IL-12 in the serum were higher in control group than in obese patients (p=0.009, p=0.004, p=0.002, respectively). The levels of TNF- α, IL-10, and apelin did not differ substantially between the obese patients and the control group (p=0.277, p=0.711, p=0.472, respectively).Conclusion: Inflammation and altered immune response are two important components of obesity. They play a significant part in the emergence of obesity-related metabolic disorders. Alterations in adipokine levels may lead to the occurence and maintenance of insulin resistance and systemic inflammation in obesity. The results demonstrate that kynurenine, IL-4, and IL-12 have a complex role in obesity and can be used as therapeutic targets. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Pamukkale Tıp Dergisi | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.title | Investigation of the possible relation of apelin, kynurenine and IL-4/IL-10/IL-12/ Tnf-α levels with clinical and metabolic parameters in obesity | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 16 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 282 | en_US |
dc.identifier.endpage | 289 | en_US |
dc.department | Pamukkale University | en_US |
dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopus | 2-s2.0-85160739883 | en_US |
dc.identifier.trdizinid | 1163665 | en_US |
dc.institutionauthor | … | - |
item.grantfulltext | open | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection |
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