Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/51870
Title: A clinical overview of paediatric sarcoidosis: Multicentre experience from Turkey
Authors: Guliyeva, Vafa
Demirkan, Fatma Gül
Yiğit, Ramazan Emre
Esen, Esra
Bayındır, Yağmur
Torun, Ruya
Kilbaş, Gülşah
Yildirim, Deniz Gezgin
Yener, Gulcin Otar
Cakan, Mustafa
Demir, Ferhat
Ozturk, Kubra
Baglan, Esra
Yuksel, Selcuk
Bakkaloglu, Sevcan A.
Makay, Balahan Bora
Kisaarslan, Aysenur Pac
Oray, Merih
Bilginer, Yelda
Omeroglu, Rukiye Eker
Ozen, Seza
Sozeri, Betul
Ayaz, Nuray Aktay
Keywords: Sarcoidosis
children
granulomatous disease
Childhood Sarcoidosis
Children
Features
Onset
Publisher: Oxford Univ Press
Abstract: Objectives We aimed to outline the demographic data, clinical spectrum, and treatment approach of sarcoidosis in a large group of patients and sought to figure out the variations of early-onset (EOS) and late-onset paediatric sarcoidosis (LOS). Methods The study followed a retrospective-descriptive design, with the analysis of medical records of cases diagnosed as paediatric sarcoidosis. Results Fifty-two patients were included in the study. The median age at disease onset and follow-up duration were 83 (28.2-119) and 24 (6-48) months, respectively. Ten (19.2%) cases had EOS (before 5th birthday) and 42 (80.7%) cases had LOS. The most common clinical findings at the time of the disease onset were ocular symptoms (40.4%) followed by joint manifestation (25%), dermatological symptoms (13.5%), and features related to multi-organ involvement (11.5%). Anterior uveitis was the most common (55%) one among ocular manifestations. Patients with EOS displayed joint, eye, and dermatological findings more commonly than patients with LOS. The recurrence rate of disease in patients with EOS (5.7%) and LOS (21.1%) were not statistically different (P = .7). Conclusions Patients with EOS and LOS may present with variable clinical features and studies addressing paediatric sarcoidosis cases in collaboration between disciplines will enhance the awareness of this rare disease among physicians and assist early diagnosis with lesser complications.
Description: Article; Early Access
URI: https://hdl.handle.net/11499/51870
https://doi.org/10.1093/mr/road050
ISSN: 1439-7595
1439-7609
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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