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https://hdl.handle.net/11499/5189
Title: | Effects of low-dose 17-ß-estradiol plus norethisterone acetate and tibolone on fasting plasma homocysteine levels in postmenopausal women | Authors: | Kaleli, Babür. Yildirim, Başak Nazan. Demir, S. Alataş, Erkan. |
Keywords: | Hormone replacement therapy Menopause and homocysteine Tibolone estradiol plus norethisterone acetate homocysteine tibolone adult article blood level controlled study diet restriction drug effect drug screening female human human experiment measurement normal human postmenopause priority journal randomization Dose-Response Relationship, Drug Drug Administration Schedule Drug Therapy, Combination Estradiol Fasting Female Homocysteine Hormone Replacement Therapy Humans Middle Aged Norethindrone Norpregnenes Postmenopause Probability Reference Values Sensitivity and Specificity |
Abstract: | Background. Many postmenopausal women currently receive hormone replacement therapy. The use of low-dose 17ß-estradiol plus norethisterone acetate and tibolone for hormone replacement therapy is not uncommon in postmenopausal women. Homocysteine, which is known to be an independent risk factor for the development of cardiovascular disease, is found in increased levels postmenopause. This study compared the effects of low-dose 17ß-estradiol plus norethisterone acetate and tibolone on the fasting plasma homocysteine level in healthy postmenopausal women. Methods. Healthy postmenopausal women (n = 44) were enrolled in the study. Women randomly assigned received 1 mg of 17ß-estradiol plus 0.5 mg of norethisterone acetate or 2.5 mg tibolone during a period of 12 weeks. Fasting plasma homocysteine levels were measured at baseline, the 4th week, and the 12th week of therapy. Results. In the 4th week there were no significant changes in plasma homocysteine levels in both groups (p > 0.05). However at the end of the 12th week the plasma homocysteine levels were reduced significantly in both groups (p < 0.05). Conclusion. Low-dose 17ß-estradiol plus norethisterone acetate and tibolone lower the fasting plasma homocysteine levels in healthy postmenopausal women. | URI: | https://hdl.handle.net/11499/5189 https://doi.org/10.1046/j.1600-0412.2003.00232.x |
ISSN: | 0001-6349 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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