Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/51977
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dc.contributor.authorSariekiz, Fatma Gizem-
dc.contributor.authorTomatir, Ayse Gaye-
dc.contributor.authorTokgun, Pervin Elvan-
dc.contributor.authorBir, Levent Sinan-
dc.date.accessioned2023-08-22T18:48:05Z-
dc.date.available2023-08-22T18:48:05Z-
dc.date.issued2023-
dc.identifier.issn0893-7648-
dc.identifier.issn1559-1182-
dc.identifier.urihttps://hdl.handle.net/11499/51977-
dc.identifier.urihttps://doi.org/10.1007/s12035-023-03470-0-
dc.description.abstractAs in many biological processes, the long non-coding RNAs (lncRNA) are currently known to have important roles in Parkinson's disease (PD). The aim of the study is to evaluate differentiated expressions of lncRNAs and their target mRNAs in the peripheral blood cells of individuals with Parkinson's disease. The peripheral blood samples were taken from 10 Parkinson's diagnosed people aging 50 years and more and from 10 healthy people as for the control group. Total RNA was isolated from peripheral blood mononuclear cells (PBMC), and a total of 5 samples were selected and evaluated by microarray analysis. lncRNAs with high fold change (fc < 1.5/fc > 1.5) were determined as a result of the analysis. Following this, the expression changes of some lncRNAs and their target mRNAs were examined by quantitative simultaneous polymerase chain reaction (qRT-PCR) in all individuals in the patient and control groups. Also, in order to determine the molecular level basic activities of lncRNAs determined by microarray analysis and which biological process and biochemical pathway they were in, Gene Ontology (GO) analysis (http:// geneo ntolo gy. org/) database was used. Thirteen upregulated and 31 downregulated lncRNAs whose expression changes were determined by microarray analysis and confirmed by qRT-PCR method were found in Parkinson's patients. As they were evaluated by GO analysis, lncRNAs were expressed differently in patient and control groups and they are found to be related with the processes such as macromolecule metabolic processes, immune system, gene expression, cell activation, ATPase activity, DNA packaging complex, signal receptor activity, immune receptor activity, and protein binding were found to be significant.en_US
dc.description.sponsorshipPamukkale University Scientific Research Projects Coordinatorship [2020SABE024]en_US
dc.description.sponsorshipThis study is supported by Pamukkale University Scientific Research Projects Coordinatorship with the project number 2020SABE024en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Neurobiologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectParkinsonen_US
dc.subjectmRNAen_US
dc.subjectlncRNAen_US
dc.subjectqRT-PCRen_US
dc.subjectMicroarrayen_US
dc.subjectPBMCen_US
dc.subjectSubstantia-Nigraen_US
dc.subjectDegenerationen_US
dc.subjectActivationen_US
dc.subjectModelen_US
dc.titleEvaluation of Long Non-coding RNA Expression Profiles in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Diseaseen_US
dc.typeArticleen_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.1007/s12035-023-03470-0-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid58296814300-
dc.authorscopusid6508246154-
dc.authorscopusid57194019069-
dc.authorscopusid55667432600-
dc.identifier.pmid37436601en_US
dc.identifier.scopus2-s2.0-85164460519en_US
dc.identifier.wosWOS:001028678600001en_US
dc.institutionauthor-
dc.identifier.scopusqualityQ1-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeArticle-
item.cerifentitytypePublications-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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